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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yu-Hang Wang

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Open access Aug 2026

Intratumoral heterogeneity as a potential biomarker for immunotherapy response and postoperative recurrence in NSCLC

Background Intratumoral heterogeneity (ITH) is associated with poor prognosis in various solid tumors. However, its use as a predictive biomarker for immunotherapy in advanced non-small cell lung cancer (NSCLC) is still lacking. Methods We used Maftools to analyze somatic variants of NSCLC from independent cohorts (POP...

Yu-Hang Wang, Xiaoying Dong, Yu-Cheng Yin et al. · 0 citations
Open access Aug 2026

Lactylation-related immune-metabolic dysregulation defines prognostic and therapeutic stratification in lung adenocarcinoma

Highlights • Single-cell analysis maps lactylation activity across the LUAD ecosystem.• Lactylation-high states show remodeled cell-cell communication networks.• A machine learning-derived LRPS predicts prognosis across cohorts.• Low LRPS is associated with greater immunotherapy benefit.• KRT7 promotes malignant LUAD p...

Meng Wang, Han Zhang, Qiuqiao Mu et al. · 1 citation

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