Lactylation-related immune-metabolic dysregulation defines prognostic and therapeutic stratification in lung adenocarcinoma

Abstract

Highlights • Single-cell analysis maps lactylation activity across the LUAD ecosystem.• Lactylation-high states show remodeled cell-cell communication networks.• A machine learning-derived LRPS predicts prognosis across cohorts.• Low LRPS is associated with greater immunotherapy benefit.• KRT7 promotes malignant LUAD phenotypes in vitro and in vivo.