Author

Yu-Jia Yang

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Oct 2026

Juglone induces GSDME-mediated pyroptosis by targeting HSP90α ATPase domain to promote STAT3 degradation in glioblastoma multiforme.

Glioblastoma (GBM) is a highly aggressive primary brain tumor with grim overall median survival, and its therapeutic efficacy is severely limited due to drug resistance. Therefore, developing effective and safe chemotherapy regimens is urgently required. Juglone, a natural bioactive constituent derived from traditional...

Hao Wu, Shuai Chen, Jia-Wen Li et al. · Toxicology and Applied Pharm... · 0 citations

#protein folding Open access Sep 2026

Multiple strategies to improve the yield of snake thrombin-like enzyme agkihpin from Gloydius halys pallas in Pichia pastoris

A multi-strategy approach in Pichia pastoris is developed to enhance the secretory expression of agkihpin, a snake venom thrombin-like enzyme that possesses thrombin-like activity and exhibits multiple functions, including inhibition of tumor invasion and metastasis.

Jia-Li Yao, Yu-Jia Yang, Wen-Jing Zhao et al. · Microbial Cell Factories · 0 citations