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Yu-Liang Dong

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Open access Sep 2026

Single-cell multi-omics dissects transcript isoform and immune repertoire dynamics in human immunosenescence.

Immunosenescence, a major hallmark of systemic aging, refers to the progressive functional decline of the immune system. This decline not only compromises host defense and immunological memory but also fuels chronic inflammation and tissue degeneration (collectively known as inflammaging). While single-cell RNA sequenc...

Yu-Hui Zheng, Zeng-Jun Ren, Ya-Fei Yang et al. · 0 citations
Jul 2026

Full-length single-cell spatial transcriptomics reveals spatial and cell-type-specific transcript isoforms in the primate brain

Fullscope-seq resolved hundreds of major isoform switches across distinct brain regions and identified DTUs between superficial and deep cortical layers and showed substantial enrichment for neuropsychiatric disorder-associated genes.

Hengxin Liu, Yanhong Hong, Y. Zhang et al. · 0 citations
Open access Aug 2026

Complete genome-derived metabolic interactions reveal the impact of gut ecology on human health.

This work leverage 1,150 complete genomes to construct genome-scale metabolic models, demonstrating that draft assemblies introduce systematic artifacts and omit critical transport functions, and connects genome completeness with microbial ecological organization and provides a framework for linking metabolic interacti...

Yu-He Gu, Haoyu Wang, Jin-Long Yang et al. · 0 citations

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