Immunosenescence, a major hallmark of systemic aging, refers to the progressive functional decline of the immune system. This decline not only compromises host defense and immunological memory but also fuels chronic inflammation and tissue degeneration (collectively known as inflammaging). While single-cell RNA sequenc...
Yu-Hui Zheng, Zeng-Jun Ren, Ya-Fei Yang et al.· Science China Life Sciences· 0 citations
Fullscope-seq resolved hundreds of major isoform switches across distinct brain regions and identified DTUs between superficial and deep cortical layers and showed substantial enrichment for neuropsychiatric disorder-associated genes.
Hengxin Liu, Yanhong Hong, Y. Zhang et al.· Nature Methods· 0 citations
This work leverage 1,150 complete genomes to construct genome-scale metabolic models, demonstrating that draft assemblies introduce systematic artifacts and omit critical transport functions, and connects genome completeness with microbial ecological organization and provides a framework for linking metabolic interacti...
Yu-He Gu, Haoyu Wang, Jin-Long Yang et al.· Cell Reports· 0 citations
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