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Author

Yu-Qian Zhang

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2 papers indexed here

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Oct 2026

Sequence Similarity Network-Guided Discovery of a Sequence-Tolerant Cyanobactin Protease Clade for Site-Selective Peptide and Protein Modification

Proteases responsible for leader peptide removal are ubiquitous in ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic pathways. However, many characterized RiPP proteases require specific core peptide modifications prior to cleavage, limiting their broader applicability. Here, we id...

Yu-Kun Zhou, Guang-Zhao Xiao, Si-Cong Yao et al. · 0 citations
#protein folding Sep 2026

De Novo Discovery of Cysteine-Targeted Reversible Covalent Cyclic Peptides with Prolonged Residence Time via Phage Display

Reversible covalent targeting of cysteine residues offers a powerful strategy for generating potent and tunable ligands, but designing electrophiles with balanced reactivity, stability, and reversible binding remains challenging. Here, we systematically optimized reversible α,β-unsaturated nitrile electrophiles and i...

Yu-Qian Zhang, Meng-Zhu Qi, Xian-Kai Liu et al. · 0 citations

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