Precision Cell Fate Engineering with CRISPR Epigenetic Editing for Regeneration and Off-the-Shelf Immunotherapy
Induced pluripotent stem cell (iPSC)-based regenerative medicine and cellular immunotherapy are severely hindered by heterogeneous cell phenotypes, unstable cellular functions and inconsistent large-scale manufacturing. Different from traditional CRISPR/Cas9 genome editing that induces DNA double-strand breaks and geno...