Author

Yuan Hou

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Open access Sep 2026

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

CSF proteomics revealed stronger APOEε4 and amyloid‐associated analyte signatures than plasma, and CSF inflammatory signaling, particularly eotaxin‐1, may serve as a correlate of longitudinal cognitive decline in cognitively normal older adults at risk for AD.

Jagan A. Pillai, Audrey Zhu, Chun-Xuan Ma et al. · Annals of Clinical and Trans... · 0 citations

#protein folding Open access Sep 2026

Catechol-O-methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis, and protein folding in schizophrenia.

Dysregulated dopamine (DA) signaling and redox homeostasis contributes to multiple neuropsychiatric and neurodegenerative disorders. Polymorphisms that influence the activity of catechol-O-methyltransferase (COMT), an enzyme critical for degrading DA in the dorsolateral prefrontal cortex, have been implicated in behavi...

S. Tripathi, Suwarna Chakraborty, Neil B. Wood et al. · Proceedings of the National... · 0 citations