Author

Yuan-Long Zhang

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#artificial intelligence Preprint Oct 2026

SpikeSSL: A Universal Spike Inference Framework with Dynamics-Informed State-Space Layers

Two-photon calcium imaging is a standard tool for recording large neural populations in vivo, yet inferring spikes accurately across the growing diversity of calcium indicators remains an open problem. Existing supervised methods achieve reasonable in-domain accuracy but generalize poorly to unseen indicators, because...

Cheng-Hao Yue, Si-Ming Xing, Shu-Ran Liu et al. · 0 citations

Sep 2026

Rapid robust high-fidelity 3D neuronal extraction from multiview calcium imaging datasets.

DeepWonder3D outperforms state-of-the-art methods in 3D localization accuracy with a tenfold reduction in computational costs, validated by numerical simulations and a hybrid two-photon/light-field imaging system.

Yu-Jia Chen, Guo-Xun Zhang, Ming-Rui Wang et al. · Nature Methods · 0 citations