From Target Discovery to Spatial Delivery: A Translational Roadmap for Gene-Targeted Therapies in Glioma
This review connects target discovery to clinical development by integrating spatial and longitudinal tumor biology with payload selection, delivery engineering, biomarker design, manufacturing, and mechanism-driven trials, and argues that the clinically actionable unit in diffuse glioma is often a target-anatomical co...
Hao Cheng, Ying-Chao Zhang, Jin-Bo Zhu et al.
· Pharmaceutics · 0 citations