Open access
Oct 2026
A Pyridoxal 5'-Phosphate-Dependent Decarboxylative Mannich Reaction Initiates Construction of the Nonpeptidic Scaffold of Kaitocephalin.
These results identify KpbH as the first native PLP-dependent enzyme that catalyzes an l-aspartate-dependent decarboxylative Mannich-type C-C bond-forming reaction and reveal a biosynthetic strategy for constructing a noncanonical amino acid-like C-C bond scaffold.
Tomohiro Noguchi, Yukari Maeno, Kazuo Furihata et al.
· Journal of the American Chem... · 0 citations