Sep 2026
Disrupted PQBP1-HNRNPU-LINE-1 axis underlies aberrant neurodevelopment in renpenning syndrome.
Jin-Yu Zhang, Wen-Zheng Qu, Xue-Jun Cheng et al.
· Molecular Psychiatry · 0 citations
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HOPX regulates the development and lineage progression of human stem cell-derived outer radial glia-like cells.
Using CRISPR-Cas9 gene editing in human pluripotent stem cells, HOPX is identified as an important regulator of oRG-like cell maintenance and the neurogenic-gliogenic balance, providing insight into the molecular programs governing human neural progenitor expansion.
Xiao-Xue Dong, Wendy W. Y. Choi, Mai Ahmed et al.
· Stem Cell Reports · 0 citations
Open access
Aug 2026
Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms
RNA splicing shapes neuronal identity and disease risk, yet current maps lack the developmental resolution and depth to resolve this complexity. Here, we integrate deep long-read RNA sequencing and proteomics in induced pluripotent stem cell-derived cortical neurons to generate a high-resolution proteogenomic atlas of...
N. Xu, Katherine M. Rynard, E. Radley et al.
· Nature Communications · 1 citation