Overexpressing FLP Recombinase Can Cause Synaptic Trafficking Defects in C. elegans
It is reported that high expression of FLPase from multi-copy extrachromosomal arrays can disrupt synaptic protein trafficking in C. elegans and supports growing awareness that tyrosine recombinases can become cytotoxic at high doses.
Z. Lenninger, F. J. Hoerndli
· bioRxiv · 0 citations