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Zhi-Lei Ge

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Oct 2026

Programming CRISPR Compartmentalization on DNA Origami for Multiplexed Biosensing

CRISPR-Cas12a has emerged as a transformative tool for nucleic acid detection and molecular diagnostics. However, achieving one-pot, orthogonal, multiplexed sensing remains challenging due to the nonspecific trans-cleavage activity of Cas12a. Here, we present a modular DNA origami-based platform that spatially confin...

L. Capelli, Ya-Ya Hao, Qien Shi et al. · 0 citations
#protein folding Sep 2026

Myelin-Inspired 3D PEGylation of Framework Nucleic Acids Enables Simultaneous Long Circulation and Rapid Renal Clearance.

This work establishes spatial conformation as a programmable parameter for regulating nanoparticle biodistribution and clearance, thereby shifting the design paradigm from compositional adjustment to architectural control and opening avenues for targeted delivery, imaging, and immunotherapy.

Qian Chen, Fei Ding, Shuang-Ye Zhang et al. · 0 citations

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