Author

Zhi-Ping P. Pang

2 papers indexed here

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Open access Sep 2026

Identification of alcohol use disorder-associated and ethanol-responsive proteins and candidate biomarkers using human cortical organoids

Genome-wide association studies of alcohol use disorder (AUD) have identified >100 loci, yet the functional impact and the downstream molecular mechanisms are not well understood. As functional effectors of genes, proteins provide direct insight into disease mechanisms. However, most proteomic alterations in postmortem...

Xin-Di Li, Andrew J. Boreland, Arpana Agrawal et al. · bioRxiv · 0 citations

Open access Sep 2026

Directing GABAergic neuronal identity from human iPSCs through developmental patterning.

It is shown that the chromatin state of the starting population constrains the neuronal identities specified by ASCL1 and DLX2, and it is demonstrated that the recurrent p.Tyr719∗ mutation disrupts interneuron maturation and subtype-associated transcriptional programs and impairs inhibitory synaptic transmission in hum...

Rui-Qi Hu, Linda L. Boshans, Yi-Ran Tao et al. · Stem Cell Reports · 0 citations