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Author

Zhi-Qiang Chen

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Open access Oct 2026

MTR4: A Conserved Youth Factor for Vascular Endothelium.

Vascular endothelial cell (VEC) senescence drives organismal aging and age-related pathologies, yet the intrinsic factors preserving endothelial youthfulness remain poorly defined. Here, we identify MTR4, an evolutionarily conserved RNA helicase and nuclear RNA exosome cofactor, as a novel regulator of VEC senescence....

Zhen-Yuan Guo, Zhi-Qiang Chen, Jia-Qi Sun et al. · 0 citations
Open access Aug 2026

Loss of BCAP31 or POLR1E Accelerates Aging in C. elegans and is Linked to Senescence in Vascular Endothelium

These findings establish BCAP31 and POLR1E as evolutionarily conserved components of a CD44‐associated network that protects against cellular senescence and organismal aging, highlighting new potential targets for mitigating age‐related vascular decline.

Mengyu Li, Zhen-Yuan Guo, Yu-Wei Jiang et al. · 0 citations
Review Jul 2026

From matrix to nucleus: CD44 as a central regulator of inflammaging, autophagy, and tissue homeostasis

Evidence is synthesized that CD44, through its structural domains, isoform diversity, and proteolytic processing, integrates extracellular cues to modulate key pathways to modulate key pathways such as STAT3, NF-κB, and the class III PI3K complex.

Syeda Ayesha Ali, Peng-Fei Qiang, Xiaojun Zhou et al. · 0 citations

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