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Author

Zhu Zhang

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Open access Aug 2026

TRIM41 stabilizes RBPJ through K63 linked ubiquitination and promotes stemness of hepatocellular carcinoma cells.

Persistent activation of the Notch signaling pathway is closely associated with the maintenance of cancer stem cells (CSCs) and the progression of hepatocellular carcinoma (HCC). Recombination signal binding protein for immunoglobulin kappa J region (RBPJ), a key transcription factor that mediates downstream target gen...

Hao Wu, Jin-Qiao Wu, Xin-Yu Zhang et al. · 0 citations
Aug 2026

Disruption of RBPJ in liver cancer-infiltrating T cells enhances antitumor immunity through remodeling epigenetic landscape.

It is found that RBPJ expression rose in exhausted T cells, aggravating their exhaustion, and acarbose-induced damage in the RBPJ transcriptional complex indicated that targeting T cell exhaustion may be a promising HCC treatment.

B. Pan, Jin-Qiao Wu, Shuyan Zhou et al. · 0 citations

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