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Disruption of RBPJ in liver cancer-infiltrating T cells enhances antitumor immunity through remodeling epigenetic landscape.

B. Pan Jin-Qiao Wu Shuyan Zhou Zeng-Bin Wang Dong-Jie Ye Zhu Zhang Yu-Xin Yao Hao Wu Xin-Yu Zhang Hao-Yi Yang N. Tang
Aug 2026 · Cell Death and Differentiation · 0 citations · 25 references
Medicine

TL;DR

It is found that RBPJ expression rose in exhausted T cells, aggravating their exhaustion, and acarbose-induced damage in the RBPJ transcriptional complex indicated that targeting T cell exhaustion may be a promising HCC treatment.

DOI PubMed Semantic Scholar
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