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Author

Zinab O. Doha

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Open access Oct 2026

Integrative Molecular Profiling and Single-Cell Characterization of LHFPL5 Reveal Cancer-Specific Regulatory Features in Clear Cell Renal Cell Carcinoma and Lung Adenocarcinoma

Background and Objectives: LHFPL5 encodes a four-pass transmembrane protein essential for cochlear mechanotransduction, but its molecular behavior in cancer remains poorly defined. We characterized the genomic, epigenetic, transcriptomic, immune, and cellular context of LHFPL5 in clear cell renal cell carcinoma (KIRC)...

Hakeemah H. Al-Nakhle, Zinab O. Doha · 0 citations
Open access Aug 2026

Tumor-Intrinsic DNA Damage Signaling Is Associated with MHC-I Expression and CD8 Cytotoxic T-Cell Engagement in Triple-Negative Breast Cancer

An exploratory, integrative analysis using single-cell RNA sequencing of TNBC patients operationally stratified into Good and Bad Prognosis groups suggests a framework in which tumor-intrinsic DNA damage signaling is associated with MHC-I antigen presentation upregulation and CD8 cytotoxic T-cell engagement, supporting...

Zinab O. Doha, E. AbuAzzah, Hakeemah H Al-Nakhle · 0 citations

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