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Zsofia M. Szegletes

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#gene editing Open access Sep 2026

Combinatorial CRISPR/Cas12a excises targeted loci in the mammalian genome at very low efficiency

The CRISPR/Cas12a system has emerged as a highly useful tool for genomic editing due to its ability to process multiple guide RNAs (gRNAs) from a single promoter. In this study, we explored the potential of combinatorial CRISPR/Cas12a to excise targeted loci in the mammalian genome by inducing double-strand breaks (DSB...

N. Anvar, Zsofia M. Szegletes, R. Steger et al. · 0 citations

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