Synthetic medical time-series generation can alleviate data scarcity and support the development of reliable clinical prediction models. However, existing methods mainly focus on matching the overall distribution and temporal dynamics of real data, which does not necessarily ensure strong downstream utility on imbalanced medical datasets. Clinically informative patterns often occur at heterogeneous temporal scales, while rare minority-class characteristics can be obscured by dominant population patterns. To address these challenges, we propose MedFlow, a class-aware multi-scale flow matching framework for medical time-series synthesis. MedFlow employs a vector-quantized multi-scale tokenizer to represent medical sequences at complementary temporal resolutions, capturing both coarse clinical trends and fine-grained dynamics. We further introduce Token Marginal Guidance, which incorporates class-conditional token statistics directly into the flow matching process to steer generation toward class-specific regions of the learned tokens. This mechanism strengthens minority-class patterns, while preserving the global and tail distributions of real data. Experiments on four public datasets covering electronic health records, EEG, and ECG signals demonstrate that MedFlow consistently outperforms recent state-of-the-art diffusion-based baselines across downstream prediction tasks. On average, it improves AUPRC by 5.8%, reduces Context-FID by 88.6%, and achieves 3.8$\times$ higher sampling throughput.
Yanhao Huang, Shibo Feng, Wanjin Feng et al.· 0 citations
Pass receiver selection is a fundamental task in football analytics, aiming to predict the intended receiver under a given game state. This task is challenging with event-centered freeze-frame observations, a broadcast-like setting that provides only partial and variable player visibility without complete trajectories or stable player identities. The model must therefore reason over anonymous visible candidates, opponent pressure, and recent context under partial observation. To address this setting, we propose a Hierarchical Possession-aware Graph Pointer Network (HPGPN), which formulates pass receiver selection as variable-size candidate prediction over visible teammates. HPGPN jointly models current player interactions, local event context, and possession-level temporal dynamics. It represents the current pass situation with a graph, incorporates fixed event context, and uses dynamic possession history to capture how the attacking sequence evolves. Candidate representations are refined hierarchically by integrating spatial, contextual, and historical evidence, and a glimpse pointer head scores the receiver candidates. Experiments on public football event and freeze-frame data show that HPGPN improves pass receiver selection performance. Ablation studies demonstrate the effectiveness of graph-based interaction modeling, fixed event context, and dual-branch dynamic possession-history modeling.
Jingyi Wang, Da Li, Kaixin Wang et al.· 0 citations
Contextualized visual personalization can retrieve a true record yet apply it to the wrong visual subject. We formalize when a record may condition an answer as \emph{record authorization}: subject presence ($P$), record-edge validity ($E$), and answer support ($S$) must all hold. We call violations visual memory misbinding (VMM). We construct RecordAuth-Diag, a 3,690-case matched diagnostic suite that changes one image--record edge while holding the query, question, record text, and image multiset fixed. Card removal and nonce relabeling attribute these failures to supplied records. Raw-bank failures span Qwen-, Phi-, and Gemma-family interfaces: Gemma-3-4B-IT reaches 63.69\% local unauthorized use at 25.75\% clean recall. CoViP remains at 26.02\%, versus 22.49\% for its Qwen backbone at similar clean recall. Typed pre-generation authorization reduces Qwen card exposure on RecordAuth-Diag from 43.63\% to 3.06\%, while positive recall changes from 86.26\% to 60.90\%. Full $P\wedge E\wedge S$ validation uses 560 localized DAVIS cases: top-1 relevance and typed authorization have comparable release (28.93\% and 28.39\%) but 6.79\% and 0.89\% unsafe release, respectively. Of the 33 additional unsafe cases removed, 27 are support, 4 edge, 2 clean, and 0 boundary cases. Thus the observed increment is an $E\wedge S$ decision dominated by support, not an edge check alone. Appearance supplies $E$ evidence only conditional on $P$; authenticated subject tokens instantiate the missing presence witness as a sufficiency control. The claims concern the evaluated contracts, not natural prevalence, consent, or visual identity
Xinyu Mao, Junsi Li, Chenyang Liu et al.· 0 citations
Proteins perform diverse cellular functions, and even single amino-acid substitutions can alter stability, activity, or molecular interactions. Protein language models (PLMs) provide a scalable approach for modeling such sequence--function relationships from unlabeled sequences, but increasing the size of dense Transformer backbones often brings substantial computational cost without consistently improving mutation-sensitive prediction. We introduce ProtLingo, an efficient PLM framework that augments a pretrained single-sequence backbone with conditional local memory and sparse expert routing. ProtLingo maps contextual residue representations into route-specific discrete codes, composes centered local windows into latent $N$-gram addresses, and retrieves reusable residual signals associated with recurring local sequence contexts. In parallel, selected feed-forward blocks are upcycled into sparse Mixture-of-Experts layers with shared and routed experts, enabling residue-dependent computation while activating only a subset of parameters. Experiments on protein fitness prediction, FLIP benchmarks, and supervised contact prediction show that ProtLingo achieves competitive performance with a 150M-scale backbone, including strong parameter efficiency on mutation-effect prediction and preserved long-range structural representations.
Mingrui Li, Sixian Shen, Minzhang Li et al.· 0 citations
Reach audiences
Advertise in front of researchers, engineers, and readers.
Autoregressive (AR) large language models formulate reasoning as token-level probabilistic sampling, which induces three fundamental defects in complex logical reasoning: error accumulation, probability substituting necessity, and the linear-chain information bottleneck. This paper proposes the Deterministic Operator-Driven Reasoning in Latent Space architecture (DODR), which reconstructs reasoning as reasoning-graph computation in a high-dimensional linear-algebraic space. Reasoning states are represented as snapshot vectors whose primitives are semantic units (phrases or sentences) rather than tokens, and each inference step is a deterministic matrix operation with no token sampling. Peirce's three inference types are formalized as three trainable matrix operators: a rank-deficient deduction operator (information collapse), a full-rank induction operator (information expansion), and an abduction operator defined as the Moore-Penrose pseudo-inverse of deduction (information hypothesizing). We prove that the operator set is minimal and complete given Peirce's trichotomy, that no single "super-operator" can realize all three types (a rank obstruction), and that reasoning graphs are Turing-complete with contractive backflow converging by Banach's fixed-point theorem. Experiments on 503 sample records (420 deduplicated samples) across dedicated and end-to-end settings show: deduction loss converges to 1.40e-05; induction achieves 0.9996 generalization coverage with 20/20 hard vetoes on counterexamples; abduction solutions exceed the random baseline by 28x with judgment accuracies of 72.5% (58/80, Wilson 95% CI [61.9%, 81.1%]) and 81.7% (49/60, CI [70.1%, 89.4%]); frozen operators attain 100% (60/60) on unseen cross-domain deduction. The architecture provides a structural zero-hallucination guarantee and a three-layer continual-learning mechanism. All data and code are released.
Diffusion language models (DLMs) offer a non-autoregressive alternative for mobile edge agentic artificial intelligence (AI) by refining tokens through iterative denoising rather than left-to-right decoding. Compared with autoregressive Transformer-based large language models (LLMs), DLMs can update multiple uncertain tokens in parallel and exploit bidirectional context throughout the generation process, enabling more flexible quality-latency trade-offs beyond fixed sequential decoding. These properties are particularly attractive for edge agents, where partial refinement, early exit, and constraint-guided correction can reduce response delay and communication overhead while improving robustness under noisy, incomplete, or dynamic contexts. This survey reviews DLM foundations and analyzes their suitability for edge settings under latency, memory, energy, bandwidth, privacy, and reliability constraints. We cover resource-efficient architectures, training and inference acceleration, compression, edge/cloud deployment, communication-aware serving, Internet of Things (IoT)/wireless applications, and evaluation of DLM-based agents. We further discuss open issues in long-context state management, split inference, trustworthy execution, multimodal grounding, and reproducible benchmarking. The goal is to connect DLM modeling properties, including bidirectionality, parallel refinement, controllability, and quality-latency elasticity, with system-level requirements of future mobile edge intelligence.
Chenqi Li, Minghui Min, Dusit Niyato et al.· 0 citations
Large language models (LLMs) increasingly rely on information retrieval (IR) systems, such as Retrieval-Augmented Generation (RAG), to incorporate domain-specific knowledge without costly re-training. These systems often store pre-computed document embeddings in cloud-based vector databases. However, such embeddings are vulnerable to embedding inversion attacks (EIAs), which can reconstruct their underlying text. Existing defenses, such as adding noise or scaling embeddings, often provide limited privacy or significantly reduce retrieval utility.
We propose SHAQ (shadow query generation), a semantic-decomposition and embedding-decoupling defense against EIAs. SHAQ is based on the insight that EIAs rely on the strong coupling between an embedding and its original text. Instead of storing document embeddings directly, SHAQ uses a generative language model to create diverse shadow queries that capture different semantic aspects of each document. These queries are then encoded and stored in place of the original document embeddings, thereby decomposing document semantics and decoupling stored embeddings from the source text.
Experiments across diverse IR datasets show that SHAQ substantially improves privacy while preserving retrieval utility, achieving a recovery rate as low as 0.2104, defending up to 19.50% more tokens than baseline defenses, and reaching up to 0.7967 MAP@10 with up to 5.53% utility improvement. These results demonstrate that semantic decomposition and embedding decoupling provide an effective alternative to directly modifying embeddings for defending against EIAs.
Xinguo Feng, Zhongkui Ma, Zihan Wang et al.· 0 citations
Large language model (LLM)-based multi-agent systems have experienced rapid growth in recent years. Despite their promise, such systems remain fragile, frequently exhibiting reasoning and coordination errors that can lead to system-level failures. Failure attribution in such systems relies on tracing natural language interactions among agents to identify the decisive error, which refers to the earliest action whose correction can reverse system failure. There are two key challenges: 1) Shallow attribution: Existing methods often capture only minor deviations, such as incomplete retrievals or formatting errors, which verification mechanisms can correct, while missing the decisive cause of system failure. 2) Contextual degradation: As the length of the system traces increases, the model's reasoning ability rapidly deteriorates. To address these challenges, we propose DCFA, a training-free framework for failure attribution. DCFA integrates a global module that constructs structured causal-inspired dependency graphs from system traces to identify the initial decisive error, and a local module that applies local counterfactual-inspired reasoning to refine causal-inspired attribution. Experiments on the Who&When benchmark across six LLMs show that DCFA improves step-level accuracy by up to 8.27% over state-of-the-art baselines.
Zehao Wang, Lanjun Wang, Shilong Jin et al.· 0 citations
In this paper, we study the problem of personalized survey response prediction using fine-tuned large language models (LLMs). This task poses unique challenges: limited per-user training data, scalability of model storage, and the need to exploit shared structure across survey questions. To address these issues, we propose Aplaud (Adaptive Personalized Low-rank and User-specific Nested Decomposition), a lightweight and scalable framework for LLM personalization. Aplaud extends the LoRA paradigm by separating adaptation into a frozen, shared low-rank basis and a compact user-specific correction, augmented with a rank-one residual for finer personalization. To further reduce per-user parameter cost and mitigate overfitting, the correction matrix can be factorized into an even lower-rank form. Empirical results demonstrate that Aplaud achieves efficient, scalable personalization across users while outperforming state-of-the-art LoRA-based personalized LLM approaches in both generalization and inference efficiency.
Xinyu Li, Ruoming Jin, Jianfeng Zhu et al.· 0 citations
Personalizing large language models (LLMs) is essential for delivering AI assistance that aligns with individual users'styles, intents, and preferences. While per-user fine-tuning can substantially enhance personalization quality, it introduces significant parameter and storage overhead, limiting scalability to large user populations. We propose PLUME (Personalized Low-Rank Adaptation through User Modulation and Shared Subspace), a lightweight framework that achieves efficient and expressive per-user adaptation by leveraging a shared task-specific subspace. Specifically, PLUME first learns a global task subspace from aggregated user data. Personalization is then achieved by training only a lightweight small square matrix within this subspace, enabling each user to obtain a tailored model while keeping shared components fixed. Cross-layer shared parameters and rank-1 residual terms are further introduced to significantly reduce redundancy while maintaining expressiveness. Experiments on multiple personalized text generation benchmarks demonstrate that PLUME achieves comparable or superior performance to strong baselines, while reducing per-user parameters by over 95%. These results establish shared-subspace modulation with minimal residuals as a scalable and semantically grounded approach to LLM personalization.
Xinyu Li, Hao Zhou, Jianfeng Zhu et al.· 0 citations
A merchant's payment processor, ledger, ERP and bank feed are updated by messages that get delayed, duplicated, dropped and reordered, so for minutes at a time the four hold contradictory beliefs about the same order. An agent resolving the exception must decide whether to ship goods, re-submit a capture, refund or wait, knowing some of those cannot be undone. We present FinalityBench, an executable benchmark for that decision. It keeps a hidden canonical event log and derives each system's view from a separately faulted delivery stream, so disagreement follows from specified fault semantics rather than being authored. Grading is on executed monetary effects: an episode is scored by the merchant's terminal economic position, relative to a privileged reference told when the pending capture resolves. The corpus of 321 tasks includes 45 twin pairs (90 tasks): tasks whose four system views are identical at the decision instant, whose authoritative probes both return unknown, and whose eventual correct dispositions differ. That snapshot indistinguishability is checked under every evaluation seed rather than assumed; equivalence over all interaction traces is not claimed. Over 14,445 graded episodes from nine programmatic policies, ranking by single-task accuracy and by paired loss disagree in 7 places: a ship-on-first-sign policy is second-best by accuracy at 65.7% and worst in the suite by paired loss, because it cannot tell the two members apart. A runtime gating irreversible actions on an authoritative finality probe reaches 85.4% and, unlike every polling policy, loses nothing to pass^5; its residual loss is almost entirely one archetype, which prices finality information directly. Language models reach the same exact rate as the hand-written gate on a stratified subset, lose about twice as much money, and discover the finality-gating strategy without being told it.
Background. Large language models (LLMs) are being adopted in biomedical research at a rapid and accelerating pace, yet commercial services that host many widely used models operate under deprecation schedules that can complicate scientific reproducibility.
Methods. We searched PubMed for original research articles from 2022 through March 2026 that applied a specific LLM to a biomedical task. An extraction agent identified model names from 61,077 article abstracts with human reviewers validating a subset for extraction accuracy. Extracted model names were normalized to canonical model identifiers. Lifecycle data (release date, retirement date, status) were compiled for the 50 most frequently used models.
Results. We identified 8,931 paper-model mentions spanning 5,242 unique publications after restricting the analysis to the 50 most frequently used models. Among these mentions, 77.7% cited a commercial closed-weight model. Overall, 42% involved a model that was already retired by the time of official publication or is scheduled to retire within two years of publication. The median interval from publication to model retirement was 538 days.
Conclusion. Many biomedical publications using LLMs are on a trajectory toward computational non-reproducibility after publication. Model deprecation should be treated as a core reporting and preservation issue for biomedical research.
Nathan Wolfrath, Meghan Conroy, Thomas Kosten et al.· 0 citations
