The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice. This has catalyzed a shift from single-step answer generation to the development of LLMs explicitly designed for medical reasoning. This paper provides the first systematic review of this emerging field. We propose a taxonomy of reasoning enhancement techniques, categorized into training-time strategies (e.g., supervised fine-tuning, reinforcement learning) and test-time mechanisms (e.g., prompt engineering, multi-agent systems). We analyze how these techniques are applied across different data modalities (text, image, code) and in key clinical applications such as diagnosis, education, and treatment planning. Furthermore, we survey the evolution of evaluation benchmarks from simple accuracy metrics to sophisticated assessments of reasoning quality and visual interpretability. Based on an analysis of 60 seminal studies from 2022-2025, we conclude by identifying critical challenges, including the faithfulness-plausibility gap and the need for native multimodal reasoning, and outlining future directions toward building efficient, robust, and sociotechnically responsible medical AI.
Zizhan Ma, Wenxuan Wang, Meidan Ding et al.· 0 citations
Synthetic data generation is increasingly used in machine learning for training and data augmentation. Yet, current strategies often rely on external foundation models or datasets, whose usage is restricted in many scenarios due to policy or legal constraints. We propose ScoreMix, a self-contained synthetic generation method to produce hard synthetic samples for recognition tasks by leveraging the score compositionality of diffusion models. The approach mixes class-conditioned scores along reverse diffusion trajectories, yielding domain-specific data augmentation without external resources. We systematically study class-selection strategies and find that mixing classes distant in the discriminator's embedding space yields larger gains, providing up to 3% additional average improvement, compared to selection based on proximity. Interestingly, we observe that condition and embedding spaces are largely uncorrelated under standard alignment metrics, and the generator's condition space has a negligible effect on downstream performance. Across 8 public face recognition benchmarks, ScoreMix improves accuracy by up to 7 percentage points, without hyperparameter search, highlighting both robustness and practicality. Our method provides a simple yet effective way to maximize discriminator performance using only the available dataset, without reliance on third-party resources. Paper website: https://parsa-ra.github.io/scoremix/.
Omni-modal dialogue models can understand multimodal inputs and synthesize spoken replies, but a spoken answer still leaves the agent visually absent. We introduce \textbf{Ex-Omni-2D}, a framework that answers a multimodal query with coordinated text, personalized speech, and reference-conditioned video. The dialogue model first writes a structured \textit{Visual Thought Plan} (VTP) for scene, emotion, and motion, then generates the response text and multi-codebook speech units. These speech units are decoded into audio and aligned with video frames, giving the speech and avatar modules a common timing signal while allowing them to learn from different data sources. The video module is trained as a full-sequence Teacher conditioned on reference appearance, VTP semantics, and frame-aligned speech units. We further explore to distill it into a few-step block-causal \emph{Streaming Student}; its Prefix Streaming mechanism carries the previous clean latent into the next chunk and is analyzed as a partial mitigation for late-chunk subject drift. At $400\times720$/$720\times400$, the four-step four-GPU Student provides incremental output with lower startup latency than the full-sequence Teacher.
Haoyu Zhang, Zhipeng Li, Xiaoying Tang et al.· 0 citations
Recent Artificial Intelligence (AI) models have matched or exceeded human experts in several benchmarks of biomedical task performance, but surgical benchmarks in particular are often missing from prominent medical benchmark suites. Since surgery requires integrating disparate tasks, generally-capable AI models could be particularly attractive as a collaborative tool if performance could be improved. On the one hand, the canonical approach of scaling architecture size and training data is attractive, especially since there are millions of hours of surgical video data generated per year. On the other hand, preparing surgical data for AI training requires significantly higher levels of professional expertise, and training on that data requires expensive computational resources. These trade-offs paint an uncertain picture of whether and to-what-extent modern AI could aid surgical practice. In this paper, we explore this question through a case study of surgical tool detection using state-of-the-art AI methods available in 2026. We demonstrate that even with multi-billion parameter models and extensive training, current Vision Language Models fall short in the seemingly simple task of tool detection in neurosurgery. Additionally, we show scaling experiments indicating that increasing model size and training time only leads to diminishing improvements in relevant performance metrics. Thus, our experiments suggest that current models could still face significant obstacles in surgical use cases. Moreover, some obstacles cannot be simply ``scaled away'' with additional compute and persist across diverse model architectures, raising the question of whether data and label availability are the only limiting factors. We discuss the main contributors to these constraints and advance potential solutions.
Kirill Skobelev, Eric Fithian, Yegor Baranovski et al.· 0 citations
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Video editing spans diverse editing paradigms, yet achieving high-quality instruction-guided and subject-guided editing within a single unified framework remains challenging. We introduce EditVid, a training-free framework combining sparse causal memory for local coherence, correspondence-based post-attention token injection for long-range identity preservation, and soft latent blending for edit locality. The same framework supports instruction-guided and reference-guided edits, including style transfer, attribute modification, object insertion, part-level editing, and subject replacement. On FiVE, EditVid achieves 78.16 FiVE-Acc, compared with 58.95 for the strongest evaluated training-free baseline, while obtaining competitive results on IVEBench. A user study further shows a 51.8\% overall preference for EditVid over 7 competing methods.
Adheesh Sunil Juvekar, Onkar Kishor Susladkar, Kiet A. Nguyen et al.· 0 citations
Weakly-Supervised Dense Video Captioning aims to localize and describe multiple events in untrimmed videos given only an ordered set of event-level captions per video. Recent work synthesizes auxiliary transition captions via LLM to provide additional vision-language alignment, but these captions lack visual grounding and are rigidly assigned to every inter-event gap at a fixed location and duration. To address these, we propose Seeing Before Synthesizing (SBS), a framework that adaptively provides visually grounded linguistic guidance only where warranted. Leveraging a VLM, we generate frame-level narratives for the inter-event gaps and detect transitions from the semantic variation across them. For identified transitions, we then refine inter-event temporal masks by blending the temporal midpoint with the semantic change point and selecting the width that maximizes vision-language alignment. Experiments on ActivityNet Captions and YouCook2 demonstrate state-of-the-art performance in both captioning and localization.
Ye-Chan Kim, Seunghee Choi, SeungJu Cha et al.· 0 citations
This paper proposes AdaRoboVLG, a task-adaptive Vision-Language-Grasp (VLG) framework that supports generalizable grasp synthesis across different robotic hands. Unlike existing VLG methods that tightly couple foundation models with end-to-end grasp policies, AdaRoboVLG learns an efficient generalizable base policy that generates and evaluates physically feasible grasp candidates through explicit kinematic mapping and force-closure-based stability estimation, while offloading task-dependent understanding to specialized foundation-model modules. These modules provide composable priors that are integrated into the grasp synthesis process, enabling contextually adaptive grasp synthesis without retraining the underlying grasp policy. Through extensive simulation and real-world experiments, we demonstrate that (i) the base policy exhibits efficient learning and strong cross-hand generalization, (ii) the framework effectively incorporates spatial, cognitive, and temporal priors to address three representative grasping challenges without compromising grasp synthesis performance compared to state-of-the-art methods, and (iii) these priors can operate jointly to enable functional grasping in cluttered and dynamic environments. These results indicate that decoupling physical grasp synthesis from task-dependent understanding provides a scalable paradigm for robotic grasping, allowing future advances in foundation models to be directly translated into improved grasp capabilities without redesigning or retraining the underlying grasp policy. Supplementary videos are available at https://adarobovlg.github.io/
Sixu Yan, Shikang Wang, Binhua Huang et al.· 0 citations
MLLM-based embedding models remain limited in compositional retrieval, often failing to distinguish scenes containing the same concepts but different attribute-object bindings. Yet the same backbone can resolve such distinctions when used as a cross-attentive reranker, motivating us to distill its compositional judgments into the embedding model. We propose CORE, which synthesizes candidate lists spanning five compositional matching levels and introduces a Rank-KL objective that trains the embedding model to reproduce the reranker's fine-grained ranking. We further introduce a graded evaluation protocol and compare contrastive learning, pairwise CoSENT, and listwise Rank-KL under the same data and tuning budget. Our comparison shows that both CoSENT and Rank-KL use the multi-level supervision more effectively than contrastive learning, with Rank-KL achieving the strongest overall performance. Across three compositional reasoning benchmarks (COLA, SUGARCREPE++, NEGBENCH), CORE-RERANKER-8B achieves an 82.7% total average, outperforming Jina-Reranker by 10.7 points, while CORE-EMBED-8B achieves the best total average (0.666) among all evaluated embedding models. The improvements transfer to the MCMR benchmark without sacrificing retrieval performance on COCO and Flickr30K.
Tingyu Song, Mingxin Li, Yanzhao Zhang et al.· 0 citations
Pathology foundation models improve transferable representation learning for histopathology, but recent gains often rely on encoders with hundreds of millions of parameters and high inference cost. We propose TAP-Path, a task-adaptive compression framework that directly restructures a pretrained Virchow2 encoder rather than distilling it into a separate student. TAP-Path combines validation-driven transformer-block selection, physical removal of redundant blocks, input-adaptive patch-token pruning, multi-depth feature recovery, and a lightweight gated task head. The final model retains 24 of 32 transformer blocks and 70% of patch tokens after pruning, reducing encoder parameters by 24.96% (631.24M to 473.70M) and analytical encoder compute by 35.20% (340.13G to 220.40G FLOPs). Across three task-head optimization seeds, TAP-Path achieved $87.98 \pm 0.067%$ test accuracy, $81.26 \pm 0.49%$ balanced accuracy, and $82.38 \pm 0.48%$ macro-F1 on a 32-class histopathology benchmark, compared with 86.89% for full Virchow2 and 87.67% for UNI2-h. TAP-Path achieved a Brier score of $0.1800 \pm 0.0005$ and failure-detection AUROC of $0.9047 \pm 0.0060$. A validation-only rare-aware objective improved rare-class balanced accuracy in a secondary operating analysis. Frozen external evaluation on 433 CPTAC samples yielded $91.22 \pm 0.83%$ accuracy and $91.10 \pm 0.81%$ balanced accuracy. These results show that task-adaptive structural and token sparsification can improve the accuracy-efficiency trade-off of large pathology foundation models while preserving reliability under internal and external evaluation.
Noisy annotations pose a significant challenge for supervised deep learning, as neural networks rely on large-scale, high-quality labeled data whose corruption can severely impair model performance. Although robustness to label noise has been extensively studied for classification tasks, it remains relatively underexplored in Pose Estimation (PE). This limitation becomes critical in clinical contexts, including neonatology, where PE of preterm infants is used to support the assessment of spontaneous motility, a key indicator of neurodevelopmental trajectories. In such settings, infants' images labeling is further hindered by visual challenges (e.g., keypoint self-occlusions, caregiver interference), making the annotation process inherently susceptible to errors. To tackle noisy annotations in PE, we introduce REliable keypoint selection via Memory of traINing Dynamics (REMIND), a clustering-based keypoint-selection strategy that exploits keypoint-wise training dynamics to identify noisy labels without assuming any prior knowledge of the noise distribution, thus enabling noise-free model training. When evaluated on the proprietary NeoPose dataset, comprising 46 videos of 46 preterm infants recorded in real clinical settings, REMIND correctly identifies noisy annotations across multiple corruption scenarios, achieving up to 93\% Area Under the Curve (AUC) with three different PE architectures used in the relevant literature. To our knowledge, this is the first study to explicitly address label noise in preterm infants' PE, paving the way for the design of trustworthy learning-based algorithms for infants'monitoring support when data quality cannot be guaranteed.
Emanuele Cardinale, Marco Proietti, Alessandro Cacciatore et al.· 0 citations
Verifying that manufactured batches of milling tools or carbide rotary burrs conform to production order sheets remains a largely manual and error-prone quality assurance task. Automating this process with computer vision faces a critical cold-start constraint since no labelled imagery is available, leaving manufacturer catalogue photography as the sole source of supervision. We investigate how far catalogue supervision can support an industrial recognition pipeline under domain shift, explicitly measuring the gap between catalogue separability and performance on held-out field photographs. Our findings reveal three key insights. First, off-the-shelf frozen feature extractors do not reliably separate the two task attributes, head shape and tooth profile, motivating targeted representation learning. Second, metric learning produces near-perfect unsupervised cluster discovery on catalogue images (adjusted Rand index 0.94--0.97), but less than half of this gain transfers to field photographs. Third, the largest transfer gains do not come from model scale or representation complexity, but from simple changes that reduce domain sensitivity: converting images to grayscale (+0.22) and constraining retrieval using the known order sheet via Hungarian assignment (+0.11). We therefore treat catalogue photography as a useful cold start rather than a deployment-ready training domain, and provide empirical baselines and an evaluation protocol for catalogue-to-field transfer in precision tool manufacturing.
Abilash Philip Madavath, Chandra Yuvesh Aubeeluck, Augustin Raju et al.· 0 citations
Medical image inpainting has the potential to improve automated brain MRI analysis by reconstructing healthy tissue within pathological regions. We introduce RARF, a task-agnostic region-aware rectified flow framework for masked data generation. We instantiate the framework for 3D brain MRI inpainting as our submission to the BraTS Inpainting Challenge 2026. RARF restricts the stochastic interpolation process to the inpainting region, while the observed voxels remain fixed and provide patient-specific anatomical context. A three-dimensional neural network receives the partially voided image, with Gaussian noise filling the missing region, together with the inpainting mask and the corresponding timestep. The model is trained using masked flow-matching and reconstruction-consistency objectives, combined with mask-aware preprocessing and data augmentation. During inference, the learned velocity field transports the initial noise toward a plausible reconstruction of the missing tissue, which is then combined with the unchanged observed anatomy. Experiments under the BraTS evaluation protocol show that the proposed approach produces competitive reconstructions while maintaining anatomical consistency. Source code is available at: https://github.com/TomasGuija/rarf.
Tomas Guija-Valiente, Blanca Rodriguez-Gonzalez, Norberto Malpica et al.· 0 citations
The visionary PhysioNet platform launched 25 years ago, based on a system developed at MIT in the 1970s. It has become one of the most comprehensive biomedical and clinical data repositories in existence.
Known for his clear and elegant writing style, Bertsekas shaped fields from control and optimization to large-scale computation and artificial intelligence.
MIT News · Artificial Intelligence· news.mit.eduJul 6, 2026
PhD student Rachel Sava, winner of the Envisioning the Future of Computing Prize, explores transformative improvements and dystopian risks of neural technology.
MIT News · Artificial Intelligence· news.mit.eduJun 30, 2026
Computer scientist Phillip Isola cuts through the hype to explain how AI agents work and what the future might hold for this rapidly advancing technology.
