This study addresses critical gaps in automated lymphoma segmentation from PET/CT images, focusing on issues often overlooked in existing literature. While deep learning has been applied for lymphoma lesion segmentation, few studies incorporate out-of-distribution testing, raising concerns about model generalizability across diverse imaging conditions and patient populations. We highlight the need to compare model performance with expert human annotators, including intra- and inter-observer variability, to understand task difficulty better. Most approaches focus on overall segmentation accuracy but overlook lesion-specific measures important for precise lesion detection and disease quantification. To address these gaps, we propose a clinically relevant framework for evaluating deep segmentation networks. Using this lesion measure-specific evaluation, we assess the performance of four deep networks (ResUNet, SegResNet, DynUNet, and SwinUNETR) across 611 cases from multi-institutional datasets, covering various lymphoma subtypes and lesion characteristics. Beyond standard metrics like the Dice similarity coefficient, we evaluate clinical lesion measures and their prediction errors. We also introduce detection criteria for lesion localization and propose a new detection Criterion 3 based on metabolic characteristics. We show that networks perform better on large, intense lesions with higher metabolic activity. Finally, we compare network performance to physicians via intra- and inter-observer variability analyses, demonstrating that network errors closely resemble those made by experts, i.e., the small and faint lesions remain challenging for both humans and networks. This study aims to improve automated lesion segmentation's clinical relevance, supporting better treatment decisions for lymphoma patients. The code is available at: https://github.com/microsoft/lymphoma-segmentation-dnn.
Shadab Ahamed, Yixi Xu, Sara Kurkowska et al.· 0 citations
OceanDepths is introduced, the first open, global, regridded AI-ready dataset that pairs satellite-derived sea surface temperature, sea surface salinity, and sea surface height products with co-located EN4 subsurface temperature and salinity profiles, complemented by matched GLORYS12 ocean reanalysis data to support comparisons or multi-stage learning.
Simon Donike, Ruben Cartuyvels, A. I. Ferola et al.· 0 citations
Can neural networks learn algebraic rules from visual inputs, or do they merely fit observed patterns? We study this question using MNIST (or EMNIST letters) as states and modular arithmetic operations as actions in a JEPA-style world model. Standard supervised and JEPA baselines with operation embeddings achieve high accuracy on seen operations but fail to extrapolate reliably to unseen operations. We propose BRo-JEPA, a world model with a block-rotation predictor that represents arithmetic operations as rotations, resulting in the cyclic structure of modular arithmetic in latent space. By applying actions as rotations, the BRo-JEPA predictor learns the rotation angles to align the latent representations with the underlying modular structure which enables strict zero-shot operation generalization. While our best block-rotation supervised baseline reaches only 54.54% zero-shot accuracy on MNIST and 25.13% on EMNIST, BRo-JEPA with a ResNet-18 encoder achieves 99.44% and 94.35% respectively, despite being trained only on the primitive operations $\pm$1. Our results suggest that world models can learn algebraic rules when the latent transformations encode the underlying modular structure. Code is available \href{https://github.com/DL-World-Models/brojepa}{here}.
Divyansh Jha, Yuanfang Xie, Brennen Yu et al.· 0 citations
This work proposes a multi-dimensional, primitive based framework for dynamic contrast-enhanced MRI reconstruction that disentangles the underlying anatomy, the dynamic contrast enhancement, and residual motion into separate temporal basis functions, thereby enabling a geometrical interpretation of the representation.
Veronika Spieker, Wenqi Huang, Cemre Ariyurek et al.· 0 citations
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This work investigates the use of auxiliary k-space magnitude information for accelerated steady-state dynamic MRI reconstruction, and demonstrates strong consistency of k-space magnitudes across time-frames.
Mahdi Saberi, Y. Alçalar, Merve Gülle et al.· 0 citations
An advanced system capable of automatically detecting complicated appendicitis from ultrasound images was developed and was explained with gradient-weighted class activation mapping (Grad-CAM), which creates a heatmap of the regions responsible for the model's prediction of the infected areas.
Fahad Ahammed, Omar Faruq Shikdar, Navid Zaman et al.· 0 citations
A novel mechanism to automatically identify which of these point-labels are suitable, and which are actively harmful, when used for propagation is introduced, paving the way for scalable ecological analysis.
César Borja, Breck A. McCollum, Jarrett E. K. Byrnes et al.· 0 citations
Results indicate the visual component is dominant but not solely responsible for skill prediction; further work is needed to conclusively disentangle transferable skill features from those bound to a specific visual domain.
Hanna Hoffmann, F. Bechtolsheim, Stefanie Speidel et al.· 0 citations
End-to-end vision-language-action (VLA) and world-action models offer an elegant route to general-purpose robotics, but their reliability is bounded by validated physical coverage. When an unfamiliar object, sensor, embodiment, or contact falls outside that coverage and no validated fallback exists, correcting the failure requires new robot data, a policy update, and regression testing. This recurring burden is the retraining tax. Unlike text, embodied data must often be created by operating machines. We present Teach-and-Grow Learning (TGL), an agent-centered architecture for general robot learning. In its general form, a multimodal agent turns a few successful demonstrations into reusable Skill Blocks: closed-loop behaviors for meaningful subgoals. In a new scene, the agent grounds and composes these blocks, selects learned or geometric tools, observes the physical outcome, and revises the route when execution departs from intent. A Skill Library stores executable behavior, while structured Experience Memory carries forward success, failure, and repair. New tasks are acquired without task-specific policy retraining. Our LIBERO evaluation attains state-of-the-art performance; controlled studies expose skill induction, persistent reuse, and agent-directed adaptation. Finally, we propose the Teach-and-Grow scaling-law hypothesis: if X denotes effective reusable experience, future-task error and teaching demand should approach irreducible floors as power laws in X. The architecture therefore treats deployment as a period of continued learning, in which one task can make the next easier.
Cell mimicry arises when different cell types appear morphologically similar. Human pathologists resolve this ambiguity using surrounding tissue context, whereas current vision models either lack contextual reasoning (cell foundation models) or cannot operate at the cell level (pathology MLLMs). We present Loki-OT, which propagates region-level tissue reasoning to individual cell predictions via Unbalanced Optimal Transport, using MLLM-derived density priors as soft guidance for ambiguous cell reassignment. Loki-OT is motivated by the observation that pretrained cell foundation model features already encode discriminative information, including tissue context, but standard cell-level supervision fails to use tissue context effectively. The resulting transport plan is distilled into a lightweight student MLP classifier that learns context-aware decision boundaries within the pretrained feature space. On the independent TCGA-BRCA cohort, Loki-OT achieved lower patient-level MAE than the fully supervised in-domain PanopTILs classifier and improved F1 in epithelium-rich mimicry tissues, using 278 weak region-level MLLM estimates built on a general-domain cell foundation model. Code: https://github.com/xiangli980/Lymphocyte_Mimicry_Correction_via_Loki_OT
Xiang Li, Yuqi Wang, Casey C. Heirman et al.· 0 citations
MagViT, an interpretable multi-magnification transformer framework with scale-gated fusion and patient-level model selection, is presented, an interpretable multi-magnification transformer framework with scale-gated fusion and patient-level model selection relative to prior ViT-centered BreakHis work.
Nabil Ashab, Soumitra Kundu, Saif Mahmud Parvez et al.· 0 citations
Optizing Your Sampling (OYS), which instead treats timestep selection as a black-box optimization problem, optimizing the target metric directly with Bayesian optimization, improves both simple and sophisticated samplers such as Euler and DPM-Solver++.
Travis Zhang, Christian K. Belardi, Justin Lovelace et al.· 0 citations
The visionary PhysioNet platform launched 25 years ago, based on a system developed at MIT in the 1970s. It has become one of the most comprehensive biomedical and clinical data repositories in existence.
Known for his clear and elegant writing style, Bertsekas shaped fields from control and optimization to large-scale computation and artificial intelligence.
MIT News · Artificial Intelligence· news.mit.eduJul 6, 2026
PhD student Rachel Sava, winner of the Envisioning the Future of Computing Prize, explores transformative improvements and dystopian risks of neural technology.
MIT News · Artificial Intelligence· news.mit.eduJun 30, 2026
Computer scientist Phillip Isola cuts through the hype to explain how AI agents work and what the future might hold for this rapidly advancing technology.
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