gene editing

CodePori: Large-Scale System for Autonomous Software Development Using Multi-Agent Technology

Context: LLM-based multi-agent systems enable automation and decision support in software development, yet existing studies rely on benchmark datasets offering only binary pass-or-fail results, limiting insight into real-world applicability. Objective: This study empirically investigates the potential and limitations of LLM-based agents in autonomous software development tasks. Method: A two-phase approach was employed: developing a multi-agent system, CodePori, for automated code generation, and conducting participant-based evaluation to assess practical performance. Results: Participant feedback reveals key strengths, challenges, and areas for improvement in LLM-based multi-agent systems, highlighting aspects missed by standard code-generation benchmarks. Conclusions: While LLM-based multi-agent systems show potential for large-scale software development, successful integration requires addressing challenges such as memory limitations, hallucinations, and code smells, alongside a practitioner-centric perspective.

Can Large Language Models Serve as Data Analysts? A Multi-Agent Assisted Approach for Qualitative Data Analysis

Context: Manual qualitative data analysis is time-intensive and can compromise validity and replicability, affecting analysis design, implementation, and reporting. Large Language Models (LLMs) enable human-bot collaboration in Software Engineering (SE), but their potential for qualitative data analysis in SE remains largely unexplored. Objective: The objective of this study is to design and develop an LLM-based multi-agent system that synergizes human decision support with AI to automate various qualitative data analysis approaches. Methods: We used LLM-based multi-agents systems to assist the qualitative data analysis process, deploying 27 agents, each responsible for a specific task, such as text summarization, initial code generation, and extracting themes and patterns. Results: The main findings are: (1) the LLM-based multi-agent system accelerates the qualitative data analysis process, (2) the system effectively automates tasks such as text summarization, initial code generation, and theme extraction, and (3) the publicly accessible code facilitates validation and further evaluation. Conclusion: The proposed LLM-based multi-agent system automates qualitative data analysis process, creating opportunities for researchers and practitioners. Future improvements focus on enhancing multilingual performance and integrating continuous expert feedback. The source code of proposed system and system details can be found here: https://github.com/GPT-Laboratory/Qualitative-Analysis-with-an-LLM-Based-Agentts

TERE4AI: A Knowledge Graph-Based Tool for Generating EU AI Act Compliant Requirements

AI Sandbox: Technical Report

Collaborative AI experimentation across industry and academia requires platforms that enable rapid prototyping while preserving controlled access, tenant separation, and transparent workflows. Despite growing interest in AI sandboxes, there is still limited practical guidance on how to design and implement platforms that integrate experimentation capabilities with governance requirements. This work presents the design and implementation of a governance-aware, multi-tenant AI sandbox for structured experimentation and the generation of reusable evaluation evidence across projects and stakeholder groups. The sandbox was developed within an industry-academia collaboration based on requirements that were iteratively refined with industrial partners. Its reference architecture separates the multi-tenant user interface from the backend control plane and places execution and data-management functions in dedicated layers. The platform supports governed user onboarding, project-centered collaboration, managed access to AI services, approval workflows, audit logging, and traceable experimentation. Experiment configurations, contextual information, and governance decisions are stored as persistent records, allowing evidence and outcomes to be compared and reused across projects. The development process provides practical lessons for deploying and extending governance-aware AI sandbox platforms in collaborative research and industrial environments.

LLM-Based Multi-Agent Systems for Code Generation: A Multi-Vocal Literature Review

Large Language Models (LLMs) have enabled multi-agent systems to perform autonomous code generation for complex tasks. Despite the recent growth in research and industrial applications in this area, there is little work on synthesizing evidence from both academic and industrial sources to capture the current state of research on LLM-based multi-agent systems for code generation. To this end, we conducted a Multi-Vocal Literature Review (MLR), combining insights from both academia and industry, including peer-reviewed studies and grey literature. The aim of this study is to systematically synthesize and analyze existing knowledge on LLM-based multi-agent systems for code generation. Specifically, the review examines the motivations for their use, employed benchmarks and models, key challenges, proposed solutions, and potential directions for future research. We selected and reviewed 114 studies, and the key findings are: 1) the identified reasons for adopting multi-agent systems for code generation were classified into nine categories; 2) the models and evaluation benchmarks utilized across the studies were systematically analyzed to provide a structured overview of commonly adopted LLM configurations and assessment practices; 3) the reported challenges and corresponding solutions were synthesized into six main categories and 26 subcategories; and 4) future research directions were identified and organized into six main categories and 18 subcategories. The results of this MLR will assist researchers and practitioners in pursuing further studies and supporting the real-world adoption of multi-agent systems in industrial settings.

Autonomous Agents in Software Development: A Vision Paper

Large Language Models (LLM) and Generative Pre-trained Transformers (GPT), are reshaping the field of Software Engineering (SE). They enable innovative methods for executing many software engineering tasks, including automated code generation, debugging, maintenance, etc. However, only a limited number of existing works have thoroughly explored the potential of GPT agents in SE. This vision paper inquires about the role of GPT-based agents in SE. Our vision is to leverage the capabilities of multiple GPT agents to contribute to SE tasks and to propose an initial road map for future work. We argue that multiple GPT agents can perform creative and demanding tasks far beyond coding and debugging. GPT agents can also do project planning, requirements engineering, and software design. These can be done through high-level descriptions given by the human developer. We have shown in our initial experimental analysis for simple software (e.g., Snake Game, Tic-Tac-Toe, Notepad) that multiple GPT agents can produce high-quality code and document it carefully. We argue that it shows a promise of unforeseen efficiency and will dramatically reduce lead-times. To this end, we intend to expand our efforts to understand how we can scale these autonomous capabilities further.

Carbon-Aware Governance Gates: An Architecture for Sustainable GenAI Development

The rapid adoption of Generative AI (GenAI) in the software development life cycle (SDLC) increases computational demand, which can raise the carbon footprint of development activities. At the same time, organizations are increasingly embedding governance mechanisms into GenAI-assisted development to support trust, transparency, and accountability. However, these governance mechanisms introduce additional computational workloads, including repeated inference, regeneration cycles, and expanded validation pipelines, increasing energy use and the carbon footprint of GenAI-assisted development. This paper proposes Carbon-Aware Governance Gates (CAGG), an architectural extension that embeds carbon budgets, energy provenance, and sustainability-aware validation orchestration into human-AI governance layers. CAGG comprises three components: (i) an Energy and Carbon Provenance Ledger, (ii) a Carbon Budget Manager, and (iii) a Green Validation Orchestrator, operationalized through governance policies and reusable design patterns.

Fabrication of hollow fiber membranes via NIPS spinning system for CO2 capture

Abstract. Carbon dioxide (CO2) emissions from industrial activities remain one of the greatest contributors to global climate change. Hollow fiber membranes (HFMs) have emerged as a promising technology for post-combustion CO2 separation owing to their high surface-area-to-volume ratio and scalability. This work focuses on the fabrication of HFMs with an emphasis on gas separation, particularly CO2, using the non-solvent induced phase separation (NIPS) spinning process for HFMs fabrication. The process allows specific control over dope and bore fluid selection, and flowrates, enabling the formation of asymmetric structures with desirable porosity, mechanical strength and suitable morphology for gas separation. The fabrication of polyethersulfone (PES)-based HFMs via NIPS, with 3 wt% polyethylene glycol (PEG) as a pore-forming additive, served as a foundational and basic study framework to provide an overview of the general hollow fibre membrane fabrication process. Preliminary assessments demonstrated the suitability of the fabricated membranes for gas separation applications as per requirements of membrane-based carbon capture technologies. Scanning electron microscopy (SEM), gas permeability tests, and tensile testing all revealed improvements in morphology, porosity, and mechanical strength, implying that this method for fabricating hollow fibre membranes has significant potential for tuning hollow fibre membranes for gas separation applications. Finally, the potential of HFM-based systems for energy-efficient CO2 capture is highlighted to be explored further.

AI-driven innovation and applications in crop breeding technology

The growth rate of global grain production can no longer meet the demands arising from population expansion. Meanwhile, climate change, cultivated land degradation and environmental stress are further exacerbating the vulnerability of the food production system. Ensuring food security is fundamental to maintain the stability and sustainable development of human society. Crop breeding is the pivotal technical means to achieve this goal. Developing new crop varieties with high yield, superior quality, and multiple resistances have become the core pathway to safeguard agricultural sustainable development and global food supply. However, traditional breeding techniques suffer from long cycles, low accuracy and limited efficiency, which cannot satisfy the development requirements of modern seed industry. The rapid iteration of artificial intelligence (AI) technology has injected new intelligent momentum into the innovation of crop breeding, driving the transformation of breeding technology from traditional experience-based breeding to precise, intelligent and efficient breeding. In this review, we summarized the development of crop breeding, and focused on the innovative breakthroughs of genomic selection, precision genome editing, protein design and high-throughput phenotyping driven by AI. We also further elaborated the intelligent driving effects exerted by these technologies on key breeding links involving germplasm mining, gene function analysis, directional trait improvement, intelligent phenotypic assessment and intelligent factory breeding. Finally, we discussed the challenges and future developmental prospects of AI deployment in crop breeding, aiming to provide a reference for the innovation and industrial application of intelligent breeding technologies.

The need for product design tools in shape memory technology

On the basis of the findings in a preliminary study, it was established that information and knowledge of shape memory alloys, SMAs, are either lacking or not available in a form that fulfills the needs of the non-specialist engineering designer. These preliminary findings have been verified in an exploratory study, which contained a literature search in combination with two surveys directed towards national and international researchers and specialists in the SMA field. The results obtained in this study form the central part of a research project with the main objective of developing tools for the design of SMA-based products. The proposal for an efficient and effective product design tool is a knowledge-based engineering system with an integrated design catalogue and a material database for the synthesis activities during the engineering design process. For the analysis activities a finite element system is chosen. For less complex analyses a general mathematics program is proposed.

Guest editorial for the special section on distributed software development

Scrum in a Multiproject Environment: An Ethnographically-Inspired Case Study on the Adoption Challenges

Agile methods continue to gain popularity. In particular, the Scrum method appears to be on the verge of becoming a de-facto standard in the industry, leading the so called Agile movement. While there are success stories and recommendations, there is little scientifically valid evidence of the challenges in the adoption of Agile methods in general, and Scrum in particular. Little, if anything, is empirically known about the application and adoption of Scrum in a multi-team and multi-project situation. The authors carried out an ethnographically informed longitudinal case study in industrial settings and closely followed how the Scrum method was adopted in a 20-person department, working in a simultaneous multi-project R&D environment. Altogether 10 challenges pertinent to the case of multi-team multi-project Scrum adoption were identified in the study. The authors contend that these results carry great relevance for other industrial teams. Future research avenues arising from the study are indicated.