ABSTRACT SARS-CoV-2 infection causes diverse clinical outcomes, with men facing higher risks of severe disease. Adenosine-to-inosine (A-to-I) RNA editing mediated by ADAR enzymes governs innate antiviral immunity, yet its contribution to COVID-19 severity and sex-biased disease remains unclear. We performed epitranscri...
Jing-Yuan Wang, Ya-Di Zhao, Li-Ping Wang et al.· RNA Biology· 0 citations
This review connects target discovery to clinical development by integrating spatial and longitudinal tumor biology with payload selection, delivery engineering, biomarker design, manufacturing, and mechanism-driven trials, and argues that the clinically actionable unit in diffuse glioma is often a target-anatomical co...
Analysis code accompanying the manuscript "Landscape of Multi-Modal Programmed Cell Death and Immune Microenvironment Remodeling in Thoracic Ossification of the Ligamentum Flavum: Integrative Bioinformatic Analysis with Epitranscriptomic and Single-Cell Validation" (submitted to Journal of Clinical Medicine). Contents:...
CRISPR/Cas9 has become a versatile platform for programmable genome editing and has generated substantial interest as a therapeutic modality for inherited and acquired diseases. However, clinical translation depends not only on editing specificity but also on safe and efficient delivery of the Cas9 nuclease and guide R...
B. Yaswanth Vinayak1, D. Nagamani2, K. Dinesh3, M. Mallikarjun4, P. Mallieswari5, Are Pradeepthi6*· Zenodo (CERN European Organi...· 0 citations
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The increasing population, changing environment, decreasing agricultural land, and disturbances in the food chain are the major threats to food security. Crop production through conventional methods poses a challenge to meet the food demand of the growing population. Therefore, the inclusion of biotechnological approac...
Vedant Gautam, Debasish Pattnaik, R. K. Singh et al.· Apple Academic Press eBooks· 0 citations
CRISPR-Cas9 has demonstrated high initial editing efficiency in animal models of inherited hematological disorders and has successfully produced phenotypic improvements, manifested as an increased percentage of red blood cells in mice after transplantation, suggesting its potential therapeutic prospects for correcting...
Qiong-Wen Xu· Journal of Mechanics in Medi...· 0 citations
Esta es una versión editable de B. abortus 2308W. El objetivo de este documento es proporcionar un mecanismo simple para las actualizaciones en la anotación de genes. Abstract This is an editable version of B. abortus 2308W. The aim of this document is to provide a simple mechanism for updates in genes annotation.
Friedreich’s ataxia (FRDA) is a triplet repeat expansion disorder with multisystem, progressive symptoms caused by reduced frataxin protein levels and compromised mitochondrial function. Restoration of frataxin protein is a focus of clinical trials involving adeno-associated viral vectors, but substantial barriers exis...
L. Osborne· Journal of Clinical Investig...· 0 citations
The receptor tyrosine kinase AXL has context-dependent roles in prostate cancer (PCa). Although AXL signaling has been implicated in PCa progression, it can also promote disseminated tumor cell dormancy. Paradoxically, AXL expression has been reported to be lost in metastatic PCa. This raises two critical questions: Is...
S. Sridhar, Kabhilan Mohan, S. Kizhake et al.· bioRxiv· 0 citations
Long-chain polyunsaturated fatty acids (LC-PUFAs) are essential to the nutrition, metabolism, and physiological performance of aquatic animals. This hybrid review combines bibliometric analysis with focused thematic synthesis to examine three decades (1991–2025) of research on LC-PUFA biosynthesis in aquatic species. B...
Barrier epithelia are shielded from the external environment by their apical extracellular matrices (aECMs). The molecular complexity of aECMs has challenged understanding of their organization in vivo. To define the molecular architecture of a model aECM we generated a toolkit of 105 fluorescently tagged aECM componen...
J. M. Ragle, Murugesan Pooranachithra, Guinevere A. Ashley et al.· PLoS Biology· 0 citations
Poison exons are highly conserved exons whose inclusion creates premature termination codons and triggers nonsense-mediated decay (NMD) of the mature transcript. Despite their important role in post-transcriptional regulation, poison exons remain poorly annotated due to the lack of systematic transcriptome-wide approac...
Paolo Pigini, Huilin Xu, Yan Ji et al.· Genome biology· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
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