Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder that selectively affects motor neurons. The median survival time after diagnosis is 2 to 5 years. Oxidative stress (OS), driven mainly by reactive oxygen species (ROS), plays a central role in motor neuron (MN) degeneration. In this...
C. A. Gómez-Pérez, M. A. Ramírez-García, Petra Yescas Gómez· International Journal of Mol...· 0 citations
Progeria is an extremely rare genetic disease in which affected individuals age rapidly due to a specific mutation in the LMNA gene, which results in the production of progerin, an abnormal protein that damages cell nuclei and causes progressive multi-organ disease. AIProSaB is an Italian association founded by Sammy B...
RNA helicases participate in multiple aspects of RNA metabolism, but the functions of most helicases in malaria parasites remain poorly understood. PfDDX1 is a conserved DEAD-box RNA helicase whose role during the asexual blood-stage development of
Plasmodium falciparum
has not been defined.
Endogeno...
C. Zhuang, Ye Hu, Li-Li Zhou et al.· Parasites & Vectors· 0 citations
Abstract: Gene delivery and the various routes of administration used to deliver viral vectors constitute a rapidly evolving field, with recent success in restoring hearing in children with OTOF variants in ongoing clinical otoferlin trials. With the rise of gene therapy for major hereditary hearing disorders, both syn...
Erdem Yildiz, Christoph Arnoldner· Ear and Hearing· 0 citations
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This study provides a versatile paradigm for conditionally controlled gene editing and highlights the therapeutic potential of cGAS demethylation in reactivating cGAS-STING pathway for antitumor immunotherapy.
Hao-Yu Zhang, Ya-Jie Li, Ye-Han Wang et al.· Angewandte Chemie· 0 citations
Fasciolosis, mainly caused by the liver fluke Fasciola hepatica , is a globally distributed parasitic disease that affects both livestock and humans, generating significant economic losses and public health concerns. Current control strategies rely mainly on anthelmintic treatments, but the increasing emergence of drug...
Marta López-García, María Torres-Valle, J. González-Miguel et al.· Parasites & Vectors· 0 citations
Rabies remains one of the most lethal zoonotic neurotropic diseases affecting warm-blooded animals and humans, causing an estimated 59,000 human deaths annually despite being completely preventable. Caused by neurotropic single-stranded negative-sense RNA viruses of the genus Lyssavirus, family Rhabdoviruses, the Rabie...
Dr. Khushbu S. Rana 2 and Dr. I. H. Kalyani 3 Dr. Dharmesh R. Patel 1· Zenodo (CERN European Organi...· 0 citations
Filamentous fungi harbor numerous silent biosynthetic gene clusters (BGCs), representing an underexplored reservoir of natural products. Chemical inhibition of epigenetic regulators is an effective strategy for activating silent BGCs, but it often lacks specificity and cannot readily link activated clusters to their co...
Meng Pang, Donghui Guo, Yanling Li et al.· Synthetic and Systems Biotec...· 0 citations
The unpredictability of the emergence and re-emergence of arboviruses underscores the need for enhancing global preparedness in surveillance capacity for tracking and predicting the growth of arboviral epidemics and case-specific arboviral disease management. In particular, the development of a more advanced clinical d...
Precision therapeutics are shifting the treatment paradigm for monogenic DEEs and NDD-E from empiric seizure control toward mechanism-based targeting of dysregulated molecular pathways and gene-based disease-modifying therapies.
Debopam Samanta· Journal of Clinical Medicine· 0 citations
Hearing loss is a prevalent sensory disorder with profound social and health impacts. Although hearing aids and cochlear implants can significantly restore auditory perception, they do not address the underlying genetic causes. Inherited forms of hearing loss, often monogenic, are ideal candidates for gene therapy, par...
G. Lahlou, Maxence Cornille, Nicolas Lai et al.· Ear and Hearing· 0 citations
Epigenetic Activation of Dormant Endogenous Visual Genes via a Single-Shot Micro-Injection for the 100% Permanent Reversal of Absolute Blindness आविष्कारकर्ता / अनुसंधानकर्ता (Inventor): बंटी कुमावत (Banti Kumawat) विषय (Subject): एपिजेनेटिक एडिटिंग, मॉलिक्यूलर न्यूरो-सिग्नलिंग और जीन एक्टिवेशन (Epigenetic Editing, Mol...
Banti Kumawat· Zenodo (CERN European Organi...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
