There is sufficient evidence indicating the benefits of AI in increasing the accuracy in diagnosis, objective craniofacial evaluation, and customized treatment plans, whereas computational therapy is still experimental, and future studies need to concentrate on multicenter data sharing, multimodal explainable AI, precision genomics, and translational framework.
Yash Srivastav, S. Verma, Kamini Prajapati et al.· Journal of Pharmaceutical Re...· 0 citations
Global agriculture faces a 2050 "perfect storm": rising temperatures, elevated CO2, and compound climate stresses – heatwaves, flash droughts, and floods – that cause non-linear yield losses. The Green revolution paradigm of maximizing yield potential (Yp) is no longer sufficient. We argue that the primary breeding target must shift decisively to yield stability (Ys): consistent performance across volatile and non-analog environments. Unlike prior trait-focused reviews that catalog physiological mechanisms without breeder-ready deployment tools, here we provide a breeder-ready roadmap of 20 keystone physiological traits, each with its genetic target, validated marker, donor germplasm, heritability, yield penalty, and deployment timeline. Traits such as SUB1A (submergence), HKT1;5 (salt exclusion), and DRO1 (deep rooting) are ready for immediate marker-assisted introgression. We highlight that the time and cost for modern breeding methods are reducing i.e., marker-assisted backcrossing (2–3 years; $1.50–$5.00 per marker), genomic selection (3–5 years; $15–$40 per sample), and speed breeding (reducing cycles by up to 60%). Critically, the regulatory landscape is diverging while the United States maintains a streamlined, notification-only process for transgene-free edits, the European Union has recently adopted a new framework (April 2026) that classifies gene-edited plants into two categories, aiming to reduce the historic $15M+ barrier for category-1 equivalents. This roadmap is distinctive in its direct translation of 100 physiological traits into 20 deployable keystone targets, with explicit genetic resources, cost timelines, and regulatory pathways, making it an actionable plan rather than a theoretical framework. We conclude with time-bound milestones: universal genotyping for all MAS-ready traits by 2030, harmonization of global regulatory pathways by 2035, and broad-scale genomic prediction deployment by 2040. The roadmap is not merely a beginning; it is an actionable plan for global food security.
M. A. Nawaz, K. Golokhvast· Integrative Plant Biotechnol...· 0 citations
A virus-like particle (VLP)-based toolkit that delivers diverse CRISPR editing modalities to human monocytes, macrophages and dendritic cells with high efficiency while preserving viability and innate immune responsiveness is presented.
Hyuncheol Jung, Pascal Devant, Carter Ching et al.· Nature Biotechnology· 0 citations
Genetic engineering (GE) and gene editing may endow traits to trees such as increased biomass and the production of novel biomaterials. Long-lived organisms such as trees might be subject to biotechnology-related risks that could be different than those of annual row crops. Those risks could be relevant to production in engineered plantations and beyond plantations to natural forests. Therefore, appropriate risk regulation is important to assure biosafety of commercialized engineered trees. In addition to gene flow via sexual reproduction, vegetative reproduction might play an additional role in environmental “exposure” risk relative to transgene dispersal in GE tree plantations. While vegetative reproduction is beneficial for preserving desired genetic traits during tree propagation, it may lead to proximal clonal spread in the field. Although the environmental risks associated with vegetative reproduction of GE trees are recognized in commercial forestry, there are few field-based environmental risk assessment (ERA) studies on dispersal risks of self-propagated GE trees. GE or gene editing of target genes involved in the vegetative propagation processes may be useful to mitigate environmental risks of clonal spread through vegetative reproduction. This review provides updates for recent field test results of GE and gene edited trees. Gene candidates related to vegetative reproduction including adventitious shooting (AS) and adventitious rooting (AR) are discussed herein as a means to mitigate unintended clonal spread from GE tree plantations.
R. Grumet, Andreas W Ebert, Yongil Yang et al.· Plants· 0 citations
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Evidence on health-promoting properties, including lipid metabolism, glycemic control, muscle protein synthesis, and gut microbiota modulation, and gut microbiota modulation are summarized, supporting the potential of mycoprotein as a sustainable alternative protein source.
Daniel Junpyo Lee, Jihyun Yoon, Arthur Junghun Kim et al.· Current Opinion in Biotechno...· 0 citations
India relies on imports to meet nearly 70 % of its edible oil demand, underscoring an urgent need to improve domestic oilseed productivity. Rapeseed-mustard (Brassica juncea (L.) Czern. & Cosson), the second-largest oilseed crop in India, has experienced a yield plateau due to the exhaustion of genetic variability in conventionally bred varieties. Heterosis breeding through hybrid development offers the most promising strategy to break this stagnation, yet commercialisation remains critically dependent on efficient pollination control systems, primarily cytoplasmic male sterility (CMS). A key challenge is the “biological penalty” imposed during CMS background conversion, wherein the combining ability and heterotic potential of superior genotypes may not remain intact, necessitating rigorous re-evaluation of converted lines. Public-sector brassica hybrids have largely failed to exceed the commercial heterosis threshold of 25–35 %. This review examines the fundamental requirements for hybrid development, the historical progression of breeding systems and the current status of major CMS systems (Ogura, Moricandia, Tournefortii and others) deployed in India, along with the challenges hindering adoption. The regulatory approval of the genetically engineered hybrid DMH-11-utilising the Barnase-Barstar system marks a significant milestone, offering stable and precise pollination control independent of alien cytoplasm constraints with a demonstrated 28–37 % yield advantage. Future strategies must focus on broadening the genetic base through alien introgression, developing defined heterotic pools and integrating genomic selection, gene editing and marker-assisted selection (MAS) with conventional breeding to achieve self-sufficiency in edible oil production.
K. Chandan, C. Khushboo, Shashikant et al.· Plant Science Today· 0 citations
By connecting stress biology with translational breeding, this review provides a framework for developing climate-resilient Brassica cultivars by synthesizing recent progress in abiotic stress tolerance from physiological, genetic, epigenetic, and multi-omics perspectives.
S. Peng, Mingliang Jiang, Xiaonan Li· Horticulturae· 0 citations
This study overcomes a key bottleneck in CRISPR/Cas delivery to small insect embryos, opening new avenues for rapid, high-throughput, and cost-effective RNP delivery methods in insect embryos.
Suluguri Ramesh, Neeraj Kumar, Amalendu Ghosh· World Journal of Microbiolog...· 0 citations
It is highlighted that future OA treatment may gradually shift from symptom-oriented management toward disease-modifying therapy based on the identification of immune endotypes, and further studies are required to validate the underlying molecular mechanisms, evaluate safety, and conduct clinical trials, thereby facilitating the clinical translation of immune reprogramming strategies for OA.
Tong Wang, Wei Jiang, Xingxu Chen et al.· Frontiers in Immunology· 0 citations
This review explores how isomiR generation, miRNA strand selection, arm switching, and epitranscriptomic regulation expand the functional diversity of miRNAs in gynecologic cancers.
Y. Pérez-Navarro, C. López-Camarillo, L. C. Flores-García et al.· International Journal of Mol...· 0 citations
