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1,680 papers
Variations in individual radiosensitivity are a key determinant of radiotherapy outcomes. However, treatments are not currently biologically optimised to consider the impact of individual genetics. Radiosensitivity models which effectively predict individual responses could be used to deliver more personalised treatmen...
Despite the known importance of WNT signalling in mammalian development and various cancers, its downstream mechanistic effect on chromatin regulation remains less understood. When WNT signalling is activated, Glycogen Synthase Kinase 3 (GSK3) is inhibited, leading to dephosphorylation and nuclear accumulation of β-cat...
Fusarium venenatum is the most widely used filamentous fungus for biomass-based microbial protein production mainly used as meat analogs. However, insufficient iterative genome editing and lack of synthetic biology tools for fine-tuning gene expression limited engineering of F. venenatum for improved traits. Here, repl...
Advances in precision genome editing and increased public support suggest that the field is ready for new clinical and regulatory pathways, including therapeutic germline gene editing.
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ABSTRACT Agrobacterium tumefaciens is a powerful delivery tool for plant genetic transformation and a pivotal platform for agricultural biotechnology. However, laboratory strains of Agrobacterium have remained genetically unoptimized for decades, with genome engineering hindered by inefficient, endogenous homologous re...
Genome editing has accelerated the production of livestock models for human disease, xenotransplantation, reproductive biology, and agricultural improvement, including disease resistance, altered growth traits, and enhanced product composition.
Recent advances in the generation of livestock blastoids are summarized and how these systems can be used to study early development across livestock species and to inform next-generation reproductive technologies are discussed.
Introduction Chickens play a crucial role in global food security but are susceptible to a plethora of avian and zoonotic pathogens. Understanding the contribution of pathogen and host factors during infection is important for the design of strategies to control avian diseases, but it is hampered by the lack of reliabl...
Hunter syndrome (mucopolysaccharidosis type II, MPS II) is an X-linked lysosomal storage disorder caused by deficiency of iduronate-2-sulfatase (IDS), leading to lysosomal accumulation of glycosaminoglycans (GAGs), dermatan sulfate and heparan sulfate. Although traditionally viewed as an inherited metabolic disease, in...
Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous skeletal dysplasia characterized by systemic bone fragility. Beyond skeletal manifestations, OI is a multisystem condition involving dentinogenesis imperfecta, hearing loss, joint hyperlaxity, and cardiopulmonary complications. The diagnostic pa...
CladeForge 0.1.0 — first public release. CladeForge is a local-first, cross-platform desktop application for building, annotating and exporting phylogenetic trees with an integrated evolutionary semantic layer: the tree is treated as a hypothesis scaffold you can construct, compare and refine offline. Built on Tauri v2...
CRISPR-Cas genome editing has evolved from a bacterial adaptive immune mechanism into a validated pharmaceutical platform spanning drug discovery, direct genetic therapeutics, and molecular diagnostics. This review provides a pharmaceutically oriented synthesis of the technology’s mechanistic foundations, its evolution...
Genie 4: our new world model unlocking unprecedented realism in real-time simulation.
Generative AI
General Science
A Blog post by NVIDIA on Hugging Face
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
General Science
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