gene editing

LEGAL, SOCIAL, AND BIOETHICAL ASPECTS OF THE USE OF GENE EDITING IN HUMAN REPRODUCTION

The Plant Defense Web: Decoding Convergent Mechanisms of Tolerance to Multiple Abiotic Stresses and Building Climate-Resilient Crops

Plants are continuously exposed to an increasingly complex combination of environmental constraints rather than to individual stresses occurring in isolation. Drought, heat, salinity, flooding, chilling, high light, ultraviolet-B (UV-B) radiation, nutrient imbalance, heavy metals and atmospheric pollutants can occur si...

Gene therapy for hereditary hearing loss: from molecular correction to clinical translation

The hearing aids and cochlear implants were extremely effective in restoring auditory function; however, none of these devices provides any cure to the underlying molecular disease. Recently there has been an unprecedented advancement in the multiple fields including genomic diagnostics, viral vector engineering, metho...

Precision Plant Breeding: Integrating Genome Editing with Artificial Intelligence- A Review

Precision plant breeding seeks to link biological target discovery with the development and evaluation of useful alleles in crop improvement. Genome-editing platforms, including CRISPR–Cas nucleases, base editors, prime editors, multiplex editing and cis-regulatory editing, enable targeted genomic alterations; however,...

MATURE SEED-DERIVED REGENERATION AND IN PLANTA TRANSFORMATION OF TROPICAL MAIZE (ZEA MAYS L.)

Maize (Zea mays L.) is an important cereal crop, but the application of genetic transformation in tropical germplasm is constrained by genotype-dependent regeneration and the limited availability of suitable explants. The present study evaluated mature seed-derived split internodes as an alternative explant source for...

Self-extending DNA recording with stochastic and programmed writing

Recording cellular histories requires new information to accumulate without erasing earlier records. Here we introduce Infinite Printer, a CRISPR recording architecture that couples self-extension to regeneration of a writable terminal context. A self-targeting prime-editing guide RNA (stpegRNA) directs repeat extensio...

Genetic and Epigenetic Manipulation Using CRISPR Techniques in Ewing Sarcoma.

Translating base editors: a decade of progress from the bench to the clinic.

Consumers’ Perception of Genetically Biofortified Gari in Nigeria: An Exploratory Study

Micronutrient deficiencies are a major public health challenge in sub-Saharan Africa, disproportionately affecting children under five and women of reproductive age. Deficiencies in vitamin A and iron are particularly prevalent, contributing to impaired cognitive development, weakened immune function, increased morbidi...

CRISPR - CAS MEDIATED GENOME EDITING FOR HUMAN DISEASE THERAPY: EMERGING APPLICATIONS, ADVANCEMENTS AND FUTURE PERSPECTIVES

CRISPR - Cas - mediated genome editing has emerged as a transformative technology with considerable potential for the treatment of human diseases. The ability of CRISPR-Cas systems to recognize specific nucleic acid recognize specific nucleic acid sequences and modify targeted genetic regions has expanded the possibili...

Base Editing as a Therapeutic Strategy for Autosomal Dominant Tubulointerstitial Kidney Disease caused by Pathogenic UMOD Variants

Autosomal dominant tubulointerstitial kidney disease caused by pathogenic UMOD variants (ADTKD-UMOD) is an untreatable monogenic kidney disease in which misfolded uromodulin is retained in the endoplasmic reticulum and exerts a toxic gain-of-function effect. Here we systematically evaluate the full spectrum of base edi...

The Genetic Discovery (GeDi) resource: Deep characterization of a multi-ancestry panel of human reference iPSCs for functional genomic studies

Human induced pluripotent stem cells (iPSCs) are essential tools for disease modelling, drug discovery, and functional genomics, yet the field remains anchored to a small number of reference lines, limiting our understanding of how genetic background shapes cellular phenotypes across human populations. Here we describe...