A validated CRISPR-Cas9 strategy for high extracellular β-galactosidase secretion in the clinically established S. boulardii CNCM I-745 is demonstrated, providing a foundation for future studies where the potential of the developed strains is evaluated in clinically relevant settings.
J. Carvalho, David Sáez Moreno, Carlos E. Costa et al.· Microbiology Research· 0 citations
Key CRISPR-derived tools are introduced, including base editors, prime editors, and programmable transcriptional and epigenetic regulators, and remaining challenges to stimulate future exploration of the full potential of CRISPR toolkits are outlined.
Zhen-Xiang Li, Xiang-Yu Xiong, Ren-Qi Cao et al.· Plant Physiology· 0 citations
Data support initiation of a first-in-human phase I trial of CRISPR_SCD001 for sickle patients presenting with severe pathology, and generates a clinical-grade, cryopreserved CD34+ cell product that corrects the sickle mutation, restores anti-sickling hemoglobins, and meets pre-clinical safety criteria.
M. DeWitt, Beatriz Campo-Fernández, Sohini Roy et al.· Molecular Therapy· 0 citations
Cancer‐testis antigens (CTAs) represent a unique class of tumor‐associated antigens (TAAs) with highly restricted expression in immune‐privileged tissues and widespread aberrant activation in various malignancies. Their potent immunogenicity and tumor specificity make CTAs promising targets for cancer immunotherapy. Th...
Ran-Ran Shi, Ling Ran, Tian-Tian Song et al.· Journal of Immunological Res...· 0 citations
It is demonstrated that DOR is the first member of the tomato SPPL gene family known to be associated with root development and adventitious organogenesis and Overexpression of this gene in the mutant has enabled the regeneration of plants with a wild-type phenotype.
M. Jáquez-Gutiérrez, S. Bretones, Constanza Martin-Vásquez et al.· Plant Cell Reports· 0 citations
This deposit contains the complete computational model and analysis code for a within-host study of autologous CCR5 gene-edited HIV cure. The work shows that the conversion of a patient's CD4 T cell pool to an HIV-resistant state is rate-limited by the turnover of the patient's own unedited cells rather than by any pro...
Mohammad Hamdallah· Zenodo (CERN European Organi...· 0 citations
SpectralKoopman This repository provides an implementation of the Spectral Koopman Approximation (SKA) method for stochastic reaction networks (SRNs). The code accompanies the manuscript: A spectral framework for revealing the hidden low-dimensional structure in stochastic reaction networks Ankit Gupta and Mustafa Kham...
Ankit Gupta· Zenodo (CERN European Organi...· 0 citations
The advent of CRISPR-Cas9 technology has revolutionized genome editing, enabling precise modifications to the human genome with unprecedented accuracy and sequence specificity. This review examines current mechanistic insights, translational advances, and clinical developments in gene editing, focusing on applications...
Abraham E. Ubhenin, F. Adamude, D. O. Ochalefu et al.· Nigerian Medical Journal· 0 citations
✨ Highlights Fork a session into a new writable copy. A local or imported session can be forked with its complete research history — conversation branches, Notebook records, artifact versions, literature, annotations, and private bookmarks all receive fresh identities. The source session is never altered, and imported...
Ewen, wen2zhou, Roxi et al.· Zenodo (CERN European Organi...· 0 citations
SpectralKoopman This repository provides an implementation of the Spectral Koopman Approximation (SKA) method for stochastic reaction networks (SRNs). The code accompanies the manuscript: A spectral framework for revealing the hidden low-dimensional structure in stochastic reaction networks Ankit Gupta and Mustafa Kham...
Ankit Gupta· Zenodo (CERN European Organi...· 0 citations
The 33rd Fungal Genetics Conference was held from March 17th to the 22nd at the Asilomar Conference Center in Pacific Grove, California. The conference has been held at Asilomar 24 times since it began as the “Neurospora Information Conference” in 1961. Over meals at the large round tables, it is common for attendees t...
Abigail L. LaBella, Jessie MacAlpine, Marie‐Claire Harrison et al.· G3 Genes Genomes Genetics· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
