It is demonstrated that CHD2 dosage bidirectionally regulates lysosomal function and autophagosome flux to set the tempo of neuronal maturation, and that CHD2 and lysosomal homeostasis constitute a critical molecular axis regulating the pace of cortical development across evolution and disease.
O. Leonardi, E. Lewerissa, Davide Aprile et al.· bioRxiv· 3 citations
This review discusses available methods for controlling potyvirus infection in solanaceous crops and proposes that genome editing be routinely used as part of efforts to develop resistant cultivars.
R. Hanisia, Alfred Patisenah, H. A. S. M. P. Negara et al.· Journal of Horticultural Res...· 0 citations
This repository contains the analysis code and demonstration data accompanying the INSCRIBE STAR Protocols manuscript. The workflow processes multiplexed smFISH imaging followed by ratiometric barcode readout in HEK293 cells, integrating gene-expression measurements and barcode editing levels at single-cell resolution....
Kai Hao, Amjad Askary· Zenodo (CERN European Organi...· 0 citations
Myelodysplastic syndromes are clonal hematopoietic stem cell neoplasms characterized by ineffective hematopoiesis and a variable risk of transformation to acute myeloid leukemia. This study examines the potential of CRISPR-Cas9 editing of DNMT3A, TET2, ASXL1, TP53, and SF3B1 to prevent disease progression. A narrative...
T Rufino· Zenodo (CERN European Organi...· 0 citations
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This repository contains the analysis code and demonstration data accompanying the INSCRIBE STAR Protocols manuscript. The workflow processes multiplexed smFISH imaging followed by ratiometric barcode readout in HEK293 cells, integrating gene-expression measurements and barcode editing levels at single-cell resolution....
Kai Hao, Amjad Askary· Zenodo (CERN European Organi...· 0 citations
Myelodysplastic syndromes are clonal hematopoietic stem cell neoplasms characterized by ineffective hematopoiesis and a variable risk of transformation to acute myeloid leukemia. This study examines the potential of CRISPR-Cas9 editing of DNMT3A, TET2, ASXL1, TP53, and SF3B1 to prevent disease progression. A narrative...
T Rufino· Zenodo (CERN European Organi...· 0 citations
Nearly 100% knockout efficiency and over 86.67% integration efficiency were achieved in the described experimental cases with this novel pop-in/pop-out-based editing system, which provides a new gene-editing tool for synthetic biology in Pichia pastoris.
Guo-Wei Zhao, Liang-Cheng Jiao, Yun-Chong Li et al.· Microbiology Research· 0 citations
Agriculture has always been a cornerstone of human civilization, providing food, raw materials, and employment. However, with the global population projected to reach nearly 10 billion by 2050, the demand for food production is expected to increase substantially (Godfray et al., 2010). Traditional farming methods are i...
Zorawar Singh· Zenodo (CERN European Organi...· 0 citations
The emergence of CRISPR-Cas9 genome editing has now broadened the scope of precise modification of genes that play a role in biosynthesis of secondary metabolites in medicinal plants. Medicinal plants generate a variety of bioactive compounds, such as alkaloids, terpenoids, phenylpropanoids, and glucosinolates, and the...
Hira Aftab, Ahmed Shakeel, Shakir Ahmed Khan et al.· Journal of Biomolecules Path...· 0 citations
The International Plant Genetics and Genomics (IPGG) is a leading scientific conference series that brings together researchers from around the world to advance innovation in plant genetics, genomics, and molecular breeding.IPGG serves as a dynamic platform for sharing cutting-edge research, fostering international col...
Agriculture has always been a cornerstone of human civilization, providing food, raw materials, and employment. However, with the global population projected to reach nearly 10 billion by 2050, the demand for food production is expected to increase substantially (Godfray et al., 2010). Traditional farming methods are i...
Zorawar Singh· Zenodo (CERN European Organi...· 0 citations
PRIMITIVE COMBINATORIAL ARCHITECTURE OF DNA A Probabilistic Model of Patterns, Cycles, and Structural Differentiation from Four Symbols Author: Cláudio Vicente da SilvaAffiliation: Independent Researcher — Londrina, Paraná, BrazilDate: September 17, 2026 Description This research develops a formal mathematical and conc...
Vicente da Silva· Zenodo (CERN European Organi...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.