Accurate medium- to long-range epidemic forecasting requires extrapolating high-dimensional, heterogeneous and nonstationary dynamics from partial observations. Yet hybrid models often leave implicit which observations inform which epidemic processes and how learned graph interactions modify system state. We introduce...
Despite a surge of empirical interest in the ``unreasonable effectiveness''of drastic data pruning for AI systems, a unified theoretical understanding of this phenomenon remains elusive. In this work, we provide a precise high-dimensional theory of learning under data pruning via weighted empirical risk minimization (E...
Protein foundation models increasingly support the generation of novel biological sequences, yet their reliance on large public datasets creates opportunities for adversarial manipulation of the material they learn from and retrieve. We investigate two data-only poisoning attacks against protein design systems, targeti...
Charalampos Koilakos, K. Provatas, Michail Patsakis et al.· 0 citations
Instruction-following language models can comply with requests that conflict with intended behaviors and safety alignment. We introduce a training-free weight-editing approach for reducing compliance with targeted undesirable instructions. Our method needs only forward passes on a small set of prompt pairs per target b...
Ali Ebrahimpour-Boroojeny, Xiao-Cong Yang, Samuel Schapiro et al.· 0 citations
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Faulty sensor readings can distort estimates of fuel use and carbon dioxide emissions from diesel engines. We evaluate two procedures that use relationships learned from healthy measurements to diagnose faults and guide fuel correction. The diagnosis procedure tests whether replacing a suspected faulty reading with an...
Predicting live birth before fresh embryo transfer could support shared decision-making in IVF/ICSI, but routine clinical data are small, heterogeneous, and contain pathway-dependent variables prone to outcome leakage. We aimed to construct a curated single-centre IVF/ICSI dataset and develop a prediction model suited...
Abdul Raheem Shahzad, Jin-Xin Chen, Ming Zhang et al.· 0 citations
Few-step generative models produce high-quality samples in one or a few evaluations. However, steering them toward desired properties remains difficult, especially when only black-box reward evaluations are available. While one could apply approaches developed for iterative diffusion and flow-based models, such as dire...
Woocheol Shin, Taeyoung Yun, Jiwon Sung et al.· 0 citations
Post-hoc image explanations usually show where a model looks using spatial heatmaps or indicate which channels matter using global channel scores. These separate views are limiting for multispectral data because channel relevance is often spatially localized and physically meaningful. We introduce Spectral-Spatial Inte...
Haotian Ma, Ruqi Yang, Philip Townsend· 0 citations
Score-based diffusion methods usually perturb data with Brownian Gaussian noise, corresponding to a light-tailed forward stochastic differential equation (SDE). For market time series this SDE can be a poor abstraction: limit order book (LOB) order flow is heavy-tailed, bursty, and occasionally jump-like. We study STOC...
Learned dynamical models can accurately predict trajectories while producing unreliable sensitivities when differentiated or transposed, limiting their use in inverse problems and scientific decision-making. Classical adjoints provide exact local derivatives, but a single adjoint cannot represent the nonlinear response...
INCONVENIENT is introduced, a benchmark designed to study robustness to convenience-sample bias and provides explicit control over both the direction and severity of relationship shifts, enabling a systematic assessment of robustness to convenience sampling.
Sara Rezaeimanesh, C. Klochko, Kundan Thind et al.· 0 citations
Large language model (LLM) agents for health can accumulate reusable textual skills from task feedback, such as calculation criteria, measurement time points, and formula units. Deciding which skills to retain is consequential: useful rules improve later answers, while faulty generalizations propagate errors. We propos...
A machine-learning approach called CheMeleon provides a practical way to develop new drugs or other molecules with much less detailed, expensive experimentation.
Research Manager Mike Walker reflects on a career spanning hacker culture, cybersecurity, and AI, sharing lessons about trust, teamwork, leadership, and why solving difficult problems requires curiosity, judgment, agility—and an understanding of the rules. The post Learn the rules: The hacker mindset appeared first on Microsoft Research.
Learn how Google Antigravity and our Cheminformatics Skills accelerate drug discovery workflows, search compounds, and propose novel rigidified macrocycles.
MIT News · Artificial Intelligence· news.mit.eduOct 28, 2026
Professor Paris Smaragdis develops computers with superhuman hearing for applications like speech recognition, music understanding, and environmental monitoring.
MIT News · Artificial Intelligence· news.mit.eduOct 27, 2026
Prabha Jha used her experience with MIT Open Learning’s program for senior executives to develop AI solutions for her employer, Verizon, and to write a book.
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