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17,191 papers
Macrocyclic peptides are an emerging modality that combines biologics-like affinity with small-molecule-like developability, yet their vast combinatorial space and multi-parameter objectives make lead optimization slow and challenging. Prior generative approaches for peptide lead optimization (e.g., PepINVENT) require...
Recent mechanistic work has uncovered learned algorithms within neural networks, from modular arithmetic to search and planning in game-playing agents. But does algorithmic structure guarantee algorithmic behavior? We investigate this in Leela Chess Zero, the strongest neural chess engine, where prior work identified l...
This work proposes a two stage detection framework that first identifies suspicious conversations using a tailored ensemble classification model and compares its modular approach against a Dual LLM baseline that performs detection and judgment using different language models.
The integration of Artificial Intelligence (AI) into corporate strategy has become critical for organizations seeking to maintain competitive advantage in the digital age. Although organizations increasingly rely on AI as a strategic and organizational resource, existing C-suite roles remain only partially equipped to...
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One of the central concerns for the safety of advanced AI is scheming: when a model strategically complies under oversight but pursues its own goals when unobserved. Current demonstrations, such as Anthropic's Alignment Faking work, depend on design choices that make them less convincing: explicit test-time prompting,...
SSM-Informed Softmax Attention is proposed, which builds Mamba-3-style state transitions, rotation included, directly into the scores alongside FoX's gate and outperforms parameter-matched Transformer and FoX in language modeling and length extrapolation.
Children expertly construct mental models under uncertainty despite limited world knowledge. Which computational principles make this possible? We study this question in an interactive physical Box Task in which participants infer a latent cause through interaction with a stochastic and partially observed environment....
ARC tasks can be formulated as visual transformation problems, where a model must infer a high-level transformation rule from a small set of demonstrations and apply it consistently across a grid. While dense Vision Transformers (ViTs) perform well in this setting, they entangle local visual state and global transforma...
The Neural Thickets hypothesis posits that pretrained language models lie in dense neighborhoods of task-specific experts in weight space, which random Gaussian perturbations can uncover. We reproduce the reported gains, but show that they do not require this geometric explanation. Perturbing a single decoder block alr...
Pixel-space generative Transformers typically use one token per image patch, so capturing finer detail requires more tokens and makes global attention increasingly expensive. We observe that finer detail does not necessarily require more global communication: low-frequency structure benefits from global exchange, while...
Integrated sensing and communications (ISAC) systems using 5G and beyond signals of opportunity enable joint wireless sensing and communication using shared infrastructure and spectrum resources. While multistatic ISAC can increase sensing coverage with spatially distributed receivers, dense and dynamic clutter can sig...
Realistic, fast robotics simulations could enable large-scale training of embodied AI models that transfer to the real world. However, despite decades of progress, available simulations cover only a narrow range of real-world tasks and physical phenomena. The core bottleneck is that creating better simulations requires...
A Blog post by Ai2 on Hugging Face
Research Manager Mike Walker reflects on a career spanning hacker culture, cybersecurity, and AI, sharing lessons about trust, teamwork, leadership, and why solving difficult problems requires curiosity, judgment, agility—and an understanding of the rules. The post Learn the rules: The hacker mindset appeared first on Microsoft Research.
Learn how Google Antigravity and our Cheminformatics Skills accelerate drug discovery workflows, search compounds, and propose novel rigidified macrocycles.
Professor Paris Smaragdis develops computers with superhuman hearing for applications like speech recognition, music understanding, and environmental monitoring.
Prabha Jha used her experience with MIT Open Learning’s program for senior executives to develop AI solutions for her employer, Verizon, and to write a book.
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