Ontology rankers remain useful for rare-disease diagnosis because each candidate can be traced to matched patient phenotypes. Large language models (LLMs) can generate differential diagnoses from the same patient description, but their predictions lack an equally clear evidence trail. Rather than asking which system should replace the other, we ask whether an LLM can improve the ranker without giving up its evidence. Our behavior-based fusion model examines the two ranked lists, their agreement, and the ontology support behind each candidate, and learns how much to rely on each system for the individual case. Before comparison, we remove a documented test-set leakage pathway caused by benchmark cases and ontology annotations being derived from the same publications. Across eight open LLMs, fusion improves Phenomizer Recall@1 by 7.86 percentage points on Phenopacket Store and 20.18 points on RAMEDIS. When paired with DeepSeek-V4-Flash through an API, a fusion model trained only on the other LLMs improves Recall@1 from 0.1657 to 0.2176, a 5.19-point gain, without retraining. For 90.8% of correct fused diagnoses, the disease retains candidate-level ontology evidence that can be inspected. These results show that LLMs can strengthen an established diagnostic tool without discarding the structured evidence that makes it useful.
Zhaoyang Jiang, Zhizhong Fu, Yunsoo Kim et al.· 0 citations
Radiology reports are written primarily for clinicians, and their specialized terminology often makes them difficult for patients to interpret. As a result, many patients turn to publicly available Large Language Models (LLMs) to help explain their reports, despite well-documented risks of factual inaccuracies and hallucinations. Automated lay-summary generation has emerged as a promising alternative, yet the effectiveness of retrieval-enhanced and clinically informed approaches for radiology-specific communication remains underexplored. This study investigates the extent to which Retrieval-Augmented Generation (RAG) and Named Entity Recognition (NER) improve the quality, factual consistency, and readability of automatically generated lay summaries compared with standard LLM-based generation. We develop a framework combining NER-based extraction of clinically relevant findings with a RAG mechanism for contextual grounding, evaluated across few-shot and fine-tuned variants of two models (Qwen, BioBART). Results show that NER consistently improves readability and overall quality, while RAG alone offers no benefit and can introduce hallucinations from irrelevant retrieved terms. Combining RAG with NER degrades performance in few-shot settings but improves readability when fine-tuned. Fine-tuned BioBART with NER achieves the best overall performance, highlighting entity-aware extraction as the primary driver of improved patient-friendly summaries.
GUI agents increasingly operate across websites, mobile apps, and desktop environments, yet the field still reports progress primarily through task success. We argue that practical deployment depends equally on efficiency: how much context, computation, action budget, and runtime overhead an agent consumes while succeeding. This survey studies efficient GUI agents through an end-to-end systems lens that preserves the current technical axes of observation efficiency, context and memory efficiency, action efficiency, and planner-side/system efficiency. For each subsection, we expand the seed literature through targeted search plus backward and forward citation chaining, then synthesize the dominant mechanisms, reported efficiency signals, and new overheads they introduce. Across the literature, recent progress converges on a small set of recurring ideas: selective reading instead of full-context ingestion, global-to-local visual allocation, recoverable memory rather than raw history replay, verification-aware control, and hybrid runtimes that can switch between GUI and non-GUI execution. We conclude by identifying the main open problems, including honest accounting of verifier cost, cross-benchmark comparability, and co-design of observation, memory, and execution layers under real latency and privacy constraints.
Bizhe Bai, Jiakang Yuan, Hongming Wu et al.· 0 citations
Information-theoretic measures derived from autoregressive language models are widely used to characterize the expectations that shape human reading, but whether language-variety-specific training improves such psycholinguistic alignment remains unclear. This question is still open for Cantonese, where recent NLP evaluations reported mixed benefits from Cantonese-specific training relative to Mandarin-oriented or general-purpose models. Using naturalistic Cantonese eye-tracking data, we compare two within-family adaptation contrasts: CKIP GPT-2 Tiny versus its lightly Cantonese-adapted JED351 derivative, and Qwen2.5-7B versus CantoneseLLM-7B, which underwent substantially more extensive Cantonese continued pretraining and instruction tuning. From each model, we derive lexical surprisal, POS surprisal, entropy before the target, and entropy reduction. Lexical surprisal and the joint four-metric model consistently favor CantoneseLLM-7B, followed by Qwen2.5-7B, CKIP, and JED351, whereas entropy reduction favors CKIP. These results suggest that more extensive Cantonese-specific training can be associated with stronger predictive fit, while model rankings also depend on the information-theoretic measure being evaluated.
Ziqi Zhang, Emmanuele Chersoni, Mohammad Momenian· 0 citations
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Grammatical error annotation in Chinese learner writing requires labels that are both consistent and linguistically meaningful. This paper proposes a layered scheme linking computational Chinese grammatical error correction (CGEC) with pedagogical error analysis. The scheme first identifies character- and punctuation-level orthographic errors, labeling them by edit operation and subtype. Other errors receive a three-layer core label combining edit operation, linguistic domain, and part of speech, with optional Chinese-specific extensions for aspect, modality, comparison, argument structure, and complements. Drawing on CGEC resources, learner-error taxonomies, and Mandarin grammar, the taxonomy is evaluated through a coverage analysis of automatically extracted MuCGEC edits and a preliminary consistency study in which five large language models apply it to a sample. The results support the layered approach while identifying category boundaries requiring further refinement.
As large language model (LLM) agents shift from tools to participants in human groups, a fundamental question for collective behavior is how their growing presence reshapes consensus formation. Here we study mixed human-AI groups in a collaborative description game, in which shared conventions emerge through repeated rounds of random pairwise communication. Varying the proportions of LLM agents, we identify three distinct regimes of consensus formation: low agent proportions facilitate human-led consensus, intermediate proportions disrupt convergence, and high proportions restore strong consensus while shifting it toward agent-led conventions. Crucially, these regimes differ not only in the strength of convergence, but also in the semantic grounding and communicative form of the resulting consensus: human-led consensus is more concrete, holistic, and grounded in shared real-world analogies, whereas agent-led consensus is more abstract, less information-dense, and more geometrically segmented. Mechanistically, agent influence arises from a shared linguistic prior that places agents near one another in the expression space, combined with relatively stable expression choices across rounds; humans initially resist adopting expressions from partners perceived as AI but gradually yield to conformity pressure. These findings provide evidence that AI composition can shape the emergence, content, and perceived legitimacy of group norms, making agent proportion and transparency important design variables for human-AI systems.
Knowledge editing provides an efficient way to update factual knowledge in large language models. However, malicious edits may introduce safety risks, making it necessary to reverse undesirable editing effects. Existing reversal methods for parameter-modifying edits mainly focus on global removal, which may also erase beneficial edits that should be preserved. In this paper, we study selective reversal of edited knowledge, where the goal is to reverse targeted edited facts while preserving the remaining edited facts. Based on the hypothesis that each edit is sparsely encoded within the dominant subspace of the edited matrix, we propose a spectral-based reversal framework that locates edit-sensitive components within the dominant singular subspace of edited weights. Experiments across multiple settings demonstrate the effectiveness of our method in reversing selected edits while preserving unrelated edited facts. These results suggest that different edits are sparsely encoded within dominant singular components and can be separable when the number of edits is moderate, making selective spectral reversal a promising direction for locating edit-specific components and repairing edited language models.
Weifeng Jiang, Ruirui Chen, Qianren Mao et al.· 0 citations
Scientific knowledge graphs organize entities and relations extracted from scientific literature, but they remain inherently incomplete. Missing typed links in such graphs can therefore represent plausible scientific hypotheses, such as unexplored associations between materials and applications. However, scientific hypothesis discovery is challenging because true discoveries are extremely sparse among typed candidate pairs: graph neural networks (GNNs) are efficient but unreliable for ambiguous cases, while large language models (LLMs) are knowledgeable but too costly to apply exhaustively and are not naturally grounded in graph structures. We propose HyGRAIL, a cost-aware and evidence-grounded framework that combines heterogeneous GNN triage with LLM-based hypothesis review. HyGRAIL first uses a GNN to score candidate hypotheses and identify a validation-calibrated ambiguous region, routing only graph-uncertain cases to LLM review. For each routed hypothesis, HyGRAIL retrieves node-level associations and multi-hop relational paths from the knowledge graph (KG), then converts this structured evidence into natural language through template-based or LLM-based naturalization. An LLM review agent finally judges each hard hypothesis using the naturalized evidence and validation-selected decision criteria. On MatKG, HyGRAIL achieves the best F1 score of 0.429, improving over the strongest prior baseline by 0.242 F1 points and over the GNN-only baseline by 0.322. Meanwhile, GNN triage reduces the LLM call rate by 54.36% on average. Ablation studies further show that retrieved graph evidence is crucial for reliable hypothesis verification and that compact, two-sided evidence is more effective than simply increasing retrieval quantity.
Yi-Han-Qiu-Dan Sun, Zhi-Han Zhu, Zhi-Yuan Jiang et al.· 0 citations
Large Language Models (LLMs) are increasingly deployed in interactive systems where understanding user intent precisely is paramount. A key capability for such systems is effective question clarification, especially when user queries are ambiguous or underspecified. This paper introduces a novel tri-agent framework for the robust evaluation of an LLM's ability to engage in clarifying dialogue. Our framework comprises three distinct LLM-based agents: (1) a Question Clarifying Agent (QCA), the system under evaluation, tasked with identifying ambiguities and posing clarifying questions; (2) a Respondent Agent (RA), designed to simulate human user responses, potentially including irrelevant or challenging replies; and (3) an Evaluator Agent (EA), an LLM-as-a-judge, which assesses the quality of the dialogue based on a comprehensive set of metrics. We detail a methodology for synthetic data generation in the supply chain domain as an example. We propose metrics evaluating ambiguity handling, question quality, dialogue efficiency, language appropriateness, and final intent alignment. We also briefly discuss the validation of the EA against human judgments. This work provides a structured approach to benchmark, validate, and improve the clarification capabilities of conversational LLM applications.
Instruction-tuning data are judged by quality metrics, and tuned models are judged by benchmarks, but both judgments pass through an output interface: the surface format in which an answer is written. Using gradient signatures across 12 tasks, four semantically equivalent interfaces, three model families, and controlled corruptions, we show that this interface confounds both measurements. Spectral statistics such as effective rank are provably invariant to interface rotation and empirically blind to semantic corruption, while the direction of the update carries the quality signal. The interface-varying residual is not noise: it identifies each unit's own target task perfectly across all three families. Capability itself is stored relative to the training interface: a skill that raises accuracy by more than 40 points under the training format can be nearly invisible under every other, and correcting a single generation budget flips the measured effect of fine-tuning on GSM8K from a gain into a large loss. Pre-registered interventions delimit where this geometry stops short of control. Data quality and model capability are interface-conditioned quantities, and current practice often reports the interface instead of the content.
Chengguang Gan, Hanjun Wei, Yunhao Liang et al.· 0 citations
AI is rapidly advancing neuroscience, yet many laboratories fail to fully unleash its potential due to significant interdisciplinary barriers. While pre-trained neural models for physiological data are progressing quickly, their heterogeneous architectures and modality-specific constraints hinder systematic integration, selection, and evaluation. Despite recent advances in large language model (LLM)-based agent systems for intelligent scientific applications, existing approaches often still lack the domain expertise required to effectively select and coordinate diverse neuroscience pre-trained models and handle unique data types in this domain. We present NS-Copilot, an LLM-driven multi-agent system for neuroscience analysis that autonomously supports end-to-end workflows for diverse professional tasks. It unifies domain-specific pre-trained models and supports key neuroscience modalities, including EEG and extracellular spike data, through a natural-language interface. Given raw data and a task description, NS-Copilot orchestrates agents with specialized roles for planning, adaptive control, code generation, and result synthesis, enabling analysis without dataset-specific heuristics. We evaluate NS-Copilot on neuroscience benchmarks spanning Alzheimer's disease, Parkinson's disease, and working memory spike decoding. Across 8 trials per task, the system consistently outperforms strong baselines on the primary metric, demonstrating the ability of NS-Copilot for effective and scalable neuroscience analysis.
Wuche Liu, Yiran Qiao, Linlin Hou et al.· 0 citations
Energy poverty is nearly absent from NLP-for-social-good, and the little existing work is either static retrieval/QA or relies on carbon-intensive cloud LLMs, a self-defeating "computational irony" for a humanitarian setting. We present EqGrid, a closed-loop simulation in which a low-frequency, open-weight LLM policy agent sets price and carbon bounds and targeted subsidies over a community of empirically-grounded household personas, while high-frequency multi-agent RL traders clear a continuous double auction constrained by a physical distribution grid (IEEE-33-bus with Dynamic Operating Envelopes). Our contribution is threefold and directly addresses how to measure the social impact of AI: (i) grounded personas (region-matched socio-demographics) whose load curves are checked for shape and level realism against real smart-meter data; (ii) formal energy-poverty equity metrics (Energy Burden, Gini of EB, LIHC) showing the intervention reduces burden inequality without raising net grid cost; and (iii) a compute-efficiency frontier that measures how much equity performance survives compressing the policy agent from a 235B teacher down to a sub-1B model deployable on a laptop, in estimated energy/carbon per decision. A decoupled-safety design (the LLM sets bounds; a validate-and-project grid gate executes) yields zero grid-constraint violations versus 55 under direct LLM control. On energy-poverty equity, the LLM policy lowers the Gini of energy burden to 0.305 (from 0.351) and mean burden by 28% while cutting cost (outperforming a tuned rule baseline), and a 3B-active model retains 95% of the benefit at roughly 9x lower inference energy than the teacher, with even a 0.8B on-device model retaining 92% at roughly 24x lower energy. We will release code and configs.
A new method, called CW-Net, translates the reasoning process of an autonomous vehicle’s AI system into understandable concepts that explain its behavior.
MIT News · Artificial Intelligence· news.mit.eduAug 31, 2026
With millions of users across the world, Julia has been used to conduct cutting-edge research and to design new drugs, jet engines, heat pumps, and more.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
New MIT research could lead to better materials for a fossil-fuel-free process for making the chemical that's essential to fertilizer and other products.
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