A thorough examination of the tumor microenvironment was conducted, uncovering the complex involvement of immune cells in both protecting against and promoting tumor growth and tactics employed by tumors to evade the immune system.
This narrative educational review aims to provide a comprehensive overview of recent advances in the understanding of ovarian cancer pathogenesis, the molecular mechanisms driving tumor progression, and the multifaceted role of the immune system in disease development and therapeutic response.
B. Vavrušáková, R. Bartošová, M. Hendrych et al.· Discover Oncology· 0 citations
The need for integrative approaches that combine genomic insights, advanced technologies, and personalized medicine to improve breast cancer prevention and treatment is emphasized, emphasizing the need for integrative approaches that combine genomic insights, advanced technologies, and personalized medicine to improve...
The development and drug resistance of breast cancer are closely associated with the heterogeneity of the tumor microenvironment (TME). Immunosuppressive cells, activated matrix components, abnormal vascular networks, and metabolic reprogramming within the TME collectively create a niche that promotes tumor survival. D...
Yan-Cai Liu, Yan-Ran Yang, Jiang-Long Wang et al.· Natural Products and Biopros...· 0 citations
Neuroblastoma is the most common extracranial solid tumor in children and exhibits significant variability in clinical outcomes. Our current understanding of the biology of neuroblastoma has been limited by an incomplete understanding of the complex interaction between tumor cells and the host cells within the tumor mi...
Michael J. Zobel, Christopher Riccardi, Selah McKenney et al.· Biochemical Pharmacology· 0 citations
Cellular heterogeneity in pancreatic ductal adenocarcinoma (PDAC) poses significant challenges for disease prognosis and limits the effectiveness of therapeutic strategies implemented in recent multicenter subtype-based clinical trials worldwide. A hallmark of PDAC is extensive intratumoral heterogeneity, which is la...
Xue-Yan Wu, L. Klein, M. Tu et al.· Cancer Research· 0 citations
Thyroid cancer (TC) and colorectal cancer are common malignancies of the endocrine and gastrointestinal systems, respectively, and continue to impose a substantial global disease burden. The tumor immune microenvironment (TIME) plays a central role in tumor initiation, progression, and therapeutic response; however, th...
