A Feature-Augmented Analytic Federated Architecture for Early Sepsis Detection

Abstract

The proliferation of Internet of Medical Things devices within the predictive healthcare paradigm necessitates robust, privacy-centric collaborative learning frameworks to detect and mitigate rapid clinical deterioration. Traditional federated learning methodologies, while attempting to preserve patient data locality, are fundamentally constrained by multi-round gradient synchronization protocols, imposing prohibitive communication latency and remaining susceptible to false negatives under extreme non-independent and identically distributed conditions. To address these challenges, this study introduces the Feature-Augmented Analytic Federated (FaFL) Architecture, which fundamentally replaces iterative gradient synchronization with a single-round closed-form computational paradigm. By instituting a proactive feature mixing mechanism via a decoupled zero-knowledge proof global buffer, the proposed framework empowers local grassroots nodes to neutralize extreme clinical heterogeneity in a single phase. The architecture employs a closed-form analytic solution combined with a trace-weighted absolute aggregation protocol to rigorously guarantee stochastic convergence and absolute cryptographic resilience without requiring recursive parameter exchanges. Extensive empirical evaluations against existing baselines under severe Dirichlet non-independent and identically distributed conditions and Byzantine poisoning attacks demonstrate that the framework fundamentally eradicates high false-negative rates in resource-constrained clinics. Consequently, the proposed architecture robustly guarantees generalization stability, substantially outperforms existing paradigms in predictive fidelity and computational efficiency, and establishes a new operational standard for mission-critical clinical networks.