Comutation of asxl1 and IDH2R172K enhances leukemogenesis and correlates with epigenetic activation of MAPK and AP-1 in zebrafish

Loss of cGAS disrupts H3K9me3 organization and derepresses LINE1 to cause inflammaging

SENP7 mediates deSUMOylation and deubiquitination of SP1 to promote lung adenocarcinoma progression and chemoresistance

Highlights • SENP7 protein is markedly expressed in LUAD, with a strong correlation to disease progression and adverse patient prognoses.• The depletion of SENP7 substantially impedes LUAD progression in both in vitro and in vivo.• SP1 is a bona fide target of SENP7, with SENP7-mediated deSUMOylation, deubiquitination,...

Genetic evaluation of encorafenib-associated kinases RAF1 and MAPK8 in pancreatic cancer: Exploratory mediation by circulating immune traits

Highlights • Genetically proxied RAF1 and MAPK8 expression was associated with pancreatic cancer risk.• A circulating CD4+ Treg-related phenotype showed a possible partial indirect contribution.• PheWAS detected no broad genetic pleiotropic signals at the prespecified threshold.• The findings support further study of R...

Monoallelic SH2B1 Variants in Neurodevelopmental Disorders: Phenotypic Expansion and Functional Characterization of Rare Variants

SH2B1 encodes an adaptor protein involved in metabolic regulation and body‐weight control. Although SH2B1 haploinsufficiency is a recognized contributor to obesity in 16p11.2 deletion syndrome, the relationship between rare monoallelic SH2B1 variants and neurodevelopmental disorders (NDDs) remains poorly characterized.

The Effects of Msi2 Knock down on Expression Levels of Musashi2-Numb Pathway and Genes Involved in the Proliferation and Apoptosis of Chronic Myeloid Leukemia Cells

Increasing H3K9 Methylation Level Reduces the Proliferation of Leukemic Stem Cells

Simple Summary Epigenetic alterations accumulate throughout life in hematopoietic stem and progenitor cells (HSPCs), leading to an increased risk of acute myeloid leukaemia (AML). Here, we investigated whether targeting the methylation of histone 3 at lysine 9 (H3K9 methylation) affects HSPCs upon aging and leukemogene...