Multipathway modulation of neuroinflammation and oxidative stress by hesperidin in a rat single prolonged stress model of post‐traumatic stress disorder
Aug 2026· Animal Models and Experimental Medicine· Vol 9, pp. 1661 - 1673· 0 citations· 50 references
Medicine
TL;DR
Hesperidin is a citrus‐derived flavanone glycoside that has been reported to have multitarget neuroprotective effects with antioxidant, anti‐inflammatory, and neurotrophic regulatory activities, however, its integrated effects across convergent pathological pathways in validated PTSD models remain insufficiently defined.
Abstract
Post‐traumatic stress disorder (PTSD) is a complicated neuropsychiatric disorder that is marked by long‐term neuroinflammation, oxidative stress, and poor neuroplasticity in stress‐sensitive brain areas. Hesperidin is a citrus‐derived flavanone glycoside that has been reported to have multitarget neuroprotective effects with antioxidant, anti‐inflammatory, and neurotrophic regulatory activities. However, its integrated effects across convergent pathological pathways in validated PTSD models remain insufficiently defined.
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