Combined bioactive PVA nanofibrous scaffolds loaded with Zn ascorbate MOFs and Petroselinum crispum (Parsley) extract for enhanced in-vitro and in-vivo wound healing applications

Glabridin-loaded PCL/silk fibroin core-shell nanofibers with immunomodulatory and antioxidant activities for cutaneous wound healing.

Through rational core-shell design, this study integrates antioxidant and immunomodulatory functions within a single coaxially electrospun scaffold, offering a clinically translatable strategy for chronic diabetic wound repair and the comprehensive structural and functional reconstruction of skin tissue.

Fabrication and characterization of an antioxidant and antibacterial fibrous wound dressing based on PVA/PCL incorporated with catechin hydrate and graphene oxide for chronic wound healing.

The synergistic bioactive effects of CH and GO, along with the ECM-mimicking nanofibrous architecture of the electrospun dressing, demonstrate its potential as a promising candidate for the treatment of chronic wounds.

Electrospun Chitosan/Gelatin Nanofibers Loaded with Kojic Acid and Black Elderberry Extract: Taguchi Optimization, Release Kinetics, and In Vitro Evaluation

Design and biological evaluation of antimicrobial PVA/AgNP/zeolite electrospun nanofiber wound dressings

The findings suggest that nanofiber wound dressings formulated with nanoscale materials represent a promising and effective alternative to conventional wound dressings, particularly for the therapeutic management of injuries associated with chemical, biological, radiological, and nuclear(CBRN) incidents.

Fabrication and characterisation of hydroxypropyl methylcellulose/ethyl cellulose/polyvinylpyrrolidone based composite wafers as an anti-bacterial dressing: a promising approach for curcumin delivery

Wound healing is a complicated biological process primarily involving tissue regeneration and repair. However, conditions such as infection, poor blood circulation, or long-term illnesses/chronic diseases (like diabetes) can impede the healing process and cause delayed recovery. In order to address these challenges, authors developed wafers. The prepared wafers have emerged as a promising solution due to their ease of application, excellent biocompatibility, and ability to maintain a moist wound environment. These porous, sponge-like systems can also be loaded with bioactive agents, enabling sustained and controlled drug delivery. The wafer was fabricated using solvent casting method with polymeric mixture of hydroxypropyl methyl cellulose (HPMC), ethyl cellulose (EC), and polyvinyl pyrrolidone (PVP K-30) and loaded with curcumin to promote wound healing. The loaded curcumin was dispersed using a high-speed homogeniser and lyophilized in a controlled environment. The developed wafer formulation was further characterised using scanning electron microscopy (SEM), thermogravimetry–differential thermal analysis (TG–DTA), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), tensile strength analysis, swelling index, and water vapour transmission rate. The in vitro drug release study was carried out mimicking USP 5 paddle-over-disc type dissolution apparatus and the results indicated that the created wafers have a sustained drug release while keeping the tissue moist. The anti-microbial potential of wafers was confirmed using the disc diffusion method. The developed wafer showed strong potential as an antibacterial wound dressing, providing controlled drug release along with fast-acting relief from bacterial infections.

In Vitro and In Vivo Evaluation of PVA Nanofibrous Mats Functionalized With Croton bonplandianum Baill. Leaf Extract for Wound Healing

The demand for natural wound dressings has led to the development of bioactive nanofibrous mats as a promising alternative to conventional materials. This study focuses on the fabrication and in vitro and in vivo evaluation of PVA nanofiber mats infused with Croton bonplandianum Baill. (CBB) extract for wound healing. Electrospinning was employed to produce three formulations: CBB‐35, CBB‐45, and CBB‐55 ‐ the numbers representing the CBB percentage in the electrospinning solution. SEM confirmed uniform fibers, smallest diameter 198 nm for CBB‐55. FTIR validated the successful incorporation of CBB phytochemicals within the PVA matrix. Moisture Management Testing (MMT), following AATCC‐195‐2009, demonstrated superior hydrophilicity, essential for wound healing. Antimicrobial efficacy was tested against Staphylococcus aureus (Gram‐positive) and Escherichia coli (Gram‐negative), with CBB‐55 exhibiting the highest zone of inhibition (ZOI). Cytotoxicity analysis using African green monkey kidney epithelial cells confirmed over 95% cell viability after 48 h, indicating biocompatibility. In vivo wound healing in Wistar albino rats showed rapid recovery, with CBB‐55‐treated wounds achieving complete closure within 12 days, than the control (77%), CBB‐35 (85%), and CBB‐45 (89%). These findings establish the nanofibrous mats as a promising biocompatible wound‐healing solution with enhanced antimicrobial activity, paving the way for clinical applications of bioactive plant‐based wound dressings.