Jul 2026· Colloids and Surfaces B: Biointerfaces· Vol 268 Pt 1, pp.
116011
· 0 citations· 42 references
Medicine
TL;DR
The therapeutic value of fluffy fibrous scaffold containing metal-polyphenol nanocomposites in promoting burn wound repair is demonstrated, thereby providing a new strategy for the preparation of customized multifunctional bioactive scaffolds.
Abstract
Skin burns remain challenging in clinical treatment due to their complex wound morphology, high oxidative stress, hypoxic microenvironment, and severe inflammatory response. Developing strategies for highly effective biomaterials with precise biological functions has become an urgent priority in addressing clinical challenges. This study developed a fluffy fibrous scaffold loaded with a metal-polyphenol nanocomposite (CeLut). The scaffold possesses water-retaining capacity, three-dimensional fluffiness, and interlayer porosity, which promote cell spreading, migration, and proliferation. It is capable of sustained release of luteolin and Ce ions, efficiently scavenging ROS while modulating oxygen metabolism. These synergistic effects of physics and biomaterials science rebalance the oxidative and hypoxic microenvironment of burn wounds, significantly accelerating wound healing, promoting skin regeneration, and alleviating inflammatory responses in a mouse burn model. The results showed that within 14 days after a second-degree burn, the recovery rate of functional skin structure reached 96.3%. These findings demonstrate the therapeutic value of fluffy fibrous scaffold containing metal-polyphenol nanocomposites in promoting burn wound repair, thereby providing a new strategy for the preparation of customized multifunctional bioactive scaffolds.
Findings suggest that the synthesized hydrogel (BSG‐CHI) provides a favorable microenvironment for tissue regeneration and wound management applications.
Durgesh Kumar, Suhela Tyeb, Baby Shruit Shukla et al.· MedComm – Biomaterials and A...· 0 citations
Through rational core-shell design, this study integrates antioxidant and immunomodulatory functions within a single coaxially electrospun scaffold, offering a clinically translatable strategy for chronic diabetic wound repair and the comprehensive structural and functional reconstruction of skin tissue.
Kexin Feng, Xiaoyu Wang, Zichao Cai et al.· Journal of materials chemist...· 0 citations
Burn wounds are challenging to heal due to irregular tissue architecture, high bacterial susceptibility, excessive oxidative stress, and prolonged inflammation. Here, we report a multifunctional sprayable hydrogel (PM) by integrating MoB (MBene) nanosheets into a thermoresponsive Pluronic F127 matrix for comprehensive burn wound therapy. Benefiting from electron-deficient boron sites and multivalent Mo states, MoB exhibits robust SOD- and CAT-mimetic activities, enabling efficient ROS scavenging, restoration of mitochondrial homeostasis, and macrophage polarization toward an anti-inflammatory M2 phenotype. Meanwhile, MoB shows high photothermal conversion efficiency, endowing the hydrogel with potent photothermal antibacterial activity, achieving >90% bacterial inhibition. In vivo studies demonstrate that PM hydrogel combined with light irradiation effectively remodels the wound microenvironment and markedly accelerates healing of infected burn wounds, reaching a 94% healing rate by day 14. Transcriptomic analyses further reveal that PM promotes tissue repair by modulating immune responses, enhancing cell migration and differentiation, and activating wound-regeneration-related pathways. Overall, this MoB-empowered sprayable hydrogel represents a promising, translatable platform integrating antioxidative, immunomodulatory, and antibacterial functions for effective management of infected burn wounds.
Chunhong Chen, Jiangshan Liu, Xulu Ma et al.· Small· 0 citations
The complex microenvironment of diabetic wounds poses a formidable challenge to tissue repair, particularly due to the absence of a functional neurovascular network. In this study, we developed a multifunctional Janus-structured scaffold (PLGA-PCL+CS+Cu-TA NS+P2, PCTP) by integrating chitosan (CS) electrospun fibers with PLGA-PCL coaxial electrospun fibers loaded with tannic acid (TA)-copper nanosheets (NSs). The NSs were loaded with PTHrP-2 to enhance bioactivity. The unique "core-shell" design protects the drug and ensures efficient release. The Janus architecture rationally manages wound exudate while maintaining a moist microenvironment conducive to healing. Moreover, PCTP exhibits excellent mechanical properties and sustained release kinetics. Its potent antioxidant and antibacterial activities effectively scavenge reactive oxygen species, protect mitochondrial integrity, and delay cellular senescence. Crucially, PCTP accelerates the regeneration of dermal fibers and epidermis structures while promoting concurrent neurogenesis and angiogenesis, thereby restoring both structural integrity and functional competence. In diabetic rat models, PCTP significantly enhanced vascularization, collagen deposition, and inflammation modulation. Collectively, this multifunctional scaffold represents a promising therapeutic strategy for achieving integrated structural and functional skin regeneration in the challenging diabetic milieu.
Zouwei Li, Renxin Chen, Yezheng Wang et al.· Advanced Healthcare Material...· 0 citations
Overall, this study provides a pH-responsive, nanozyme-integrated fibrous membrane with combined antibacterial and pro-regenerative functions, offering a promising strategy for the treatment of bacteria-infected wounds without relying on antibiotics.
Han Lin, Jingyan Huang, Xiaoqi Xie et al.· Colloids and Surfaces B: Bio...· 0 citations
Chronic diabetic wounds remain a major clinical challenge owing to persistent bacterial infection, prolonged inflammation, excessive exudation, and impaired tissue regeneration. Herein, an injectable thermosensitive hydrogel was developed by integrating N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride with aldehyde-functionalized Pluronic F127 for epidermal growth factor (EGF) delivery and diabetic wound repair. The hydrogel forms a dual-crosslinked network through temperature-induced micellization and dynamic Schiff base bonding, exhibiting rapid gelation under physiological conditions, shear-thinning behavior, and self-healing properties. In vitro, the hydrogel provides a sustained release profile of EGF exhibiting effective antibacterial activity against Gram-positive S. aureus. In vivo studies in streptozotocin-induced diabetic rats demonstrate significantly accelerated wound healing, achieving 83% wound closure within 14 days compared to 45% in the control group, along with enhanced tissue regeneration characteristics, including improved collagen deposition. This multifunctional hydrogel provides a promising strategy for diabetic wound management by integrating antibacterial potential and tissue regeneration.
