Jul 2026· International Journal of Pharmaceutical Quality Assurance· Vol 16· 0 citations· 19 references
TL;DR
Serum IRISIN levels are significantly high in COPD patients with pulmonary rehabilitation compared to COPD patients without pulmonary rehabilitation as hypothesized, suggesting IRISIN may also reflect changes in domains other than airflow limitation in COPD patients.
Abstract
Introduction: Chronic obstructive pulmonary disease (COPD) is one of the most common causes of disease burden
both globally and in India it needs more emphasis than ever, the third leading cause of death in India and globally.
There is a need for more diagnostic and therapeutic options. We studied Serum IRISIN in hope of finding a new
biomarker for COPD. Serum IRISIN is a skeletal muscle protein associated with physical activity, the levels of
which are increased in COPD patients after 8 weeks of pulmonary rehabilitation. There is no Indian data available
on IRISIN in COPD patients.
Objective:
Primary objective of our study is to assess the level of serum IRISIN level in COPD before starting Pulmonary
Rehabilitation and after 8 weeks of Pulmonary Rehabilitation.
Secondary objective is to study correlation between IRISIN and spirometry, 6 minute walk test, Clinical features,
Dyspnea score and Quality of life.
Methodology: Cases were selected from OPD department of Pulmonary Medicine JSS Hospital Mysore. 80 subjects
satisfying inclusion and exclusion criteria underwent PFT, 6MWT, SGRQ-C, CAT score, BODE index and ELISA
for serum IRISIN levels. Statistical analysis included, Chi2 test/Fisher extract test, One, Independent t Test, Mann
Whitney test, Pearson correlation test and spearman correlation test.
Results: The mean age of the study group was 62.4 ± 9.8. Male subjects in the study were 50 and female subjects
were 30. There is a significant increase in IRISIN levels between COPD (control group, no pulmonary rehabilitation)
and COPD (intervention group, with pulmonary rehabilitation) with significant p value <0.001.
Conclusion: IRISIN levels are significantly high in COPD patients with pulmonary rehabilitation compared to
COPD patients without pulmonary rehabilitation as hypothesized. (p value <0.001). Serum IRISIN levels correlate
well with quality of life suggesting IRISIN may also reflect changes in domains other than airflow limitation in
COPD patients. There is no significant difference in serum IRISIN levels among male and female COPD patients,
suggesting that levels of IRISIN are independent of age
The six-minute step test (6MST) is a valuable assessment to determine functional capacity in people with chronic obstructive pulmonary disease (COPD). However, clinical and behavioral variables, and personal characteristics, may be associated with test performance. No predictive equations are available that account for one or more of these variables in the estimation of functional capacity outcome from the 6MST. We sought to identify clinical and behavioral variables associated with 6MST outcome (total number of steps) in patients with COPD. This retrospective analysis included 122 adults, aged ≥ 50 years, with stable COPD that underwent a 6MST test. Cohort was characterized by anthropometric, medical and smoking history, comorbidities, medications, lung function (spirometry), presence of dyspnea (modified medical research council scale; mMRC), echocardiography. Univariate and multivariate regression analyses, and 5-fold cross-validation, were performed to develop and internally validate an association-based model for 6MST. Univariate linear regression reported that age, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC, mMRC, type 2 diabetes mellitus, hypertension, chronic heart failure (CHF), inhaled corticosteroid, anticoagulants, beta-blockers, and diuretics were significantly associated with 6MST (p < 0.05). Multiple regression analysis indicated that 43.2% of the variance in 6MST performance was associated with BMI, age, FEV1/FVC, current smoking status, presence of CHF and dyspnea (mMRC), and use of short-acting β-agonists (R2 adjusted 0.432; p < 0.05). Clinical and behavioral variables are associated with 6MST outcome. While warranting further confirmation, these findings contribute to better understanding multidimensional factors related to functional performance in COPD.
Aldair Darlan Santos-de-Araújo, D. Bassi-Dibai, Izadora Moraes Dourado et al.· Sport Sciences for Health· 0 citations
Background and objectives: Asthma is a globally significant non-communicable disease with major public health consequences. Objective of this study was to find out the association between serum uric acid levels and severity of airflow obstruction, to measure the serum uric acid in asthma patients and to determine the severity of asthma by FEV1.
Methodology: This cross sectional study was done in the National Institute of Diseases of the chest & Hospital (NIDCH), Mohakhali and total 110 study population who fulfilled the GINA 2019 criteria for the diagnosis of asthma in adults with e” 18 years were included. Patient with smoking, other obstructive lung diseases, gout or F/H of hyperuricemia, chronic kidney disease, hepatic failure, active malignancies or acute gastrointestinal bleeding, IHD, patients treated with diuretics and xanthine derivatives (e.g. theophyline) and pregnancy were excluded.
Results: Mean serum uric acid level 6.76 mg/dl (±0.53 mg/dl) is found significantly higher among obese patient than non-obese patients. The most common trigger was ongoing URTI. Among the participants, 24 (21.8%) had well controlled symptoms. 59 (53.6%) had partly controlled symptoms and 27 (24.6%) had uncontrolled symptoms. Significantly higher serum uric acid level was also observed in patient with partially controlled and uncontrolled asthma when compared with well controlled asthma. Significantly higher serum uric acid level was found in patient with more severe airflow obstruction when compared less severe airflow obstruction
Conclusions: Higher serum uric acid levels are associated with higher severity of asthma and poor asthma control.
Chest Heart J. 2023; 47(1) : 34-39
Leema Saha, H. Saha, Swadesh Kumar Saha et al.· Chest & Heart Journal· 0 citations
The AE non CB and AE-CB phenotypes were found to have the most significant impact on HR-QoL among COPD patients, suggesting that individuals with the AE-CB phenotype notably require a tailored treatment approach that specifically addresses both the frequent exacerbations and the chronic bronchitis component to improve their overall QoL.
Naresh Bhagora, S. Meena, Pushpendra Bairwa et al.· Journal of Clinical and Diag...· 0 citations
Background: Forced Expiratory Volume in the first second (FEV1) from spirometry is essential in diagnosing and managing COPD. Early detection of severe COPD in primary care is vital for timely referral and treatment. Spirometry is often underutilized in rural areas due to limited resources. The Fifteen Steps Climbing Exercise Oximetry Test (15SCT) offers an alternative for assessing COPD severity.
Objective: To evaluate the efficacy of 15SCT in determining disease severity in stable COPD patients.
Methods: This cross-sectional study was conducted at the National Institute of Diseases of the Chest and Hospital (NIDCH) from June 2022 to August 2023, involving 116 stable COPD patients. Spirometry confirmed COPD diagnosis and severity grading. Pulse, respiratory rate, and oxygen saturation (SpO2) were measured pre- and post-15SCT. Data were analyzed using SPSS v.23, employing Paired t-test, Unpaired t-test, and ROC curve analysis.
Results: Patients (mean age 61.3±8.1 years; M:F = 22.2:1) showed moderate (50.0%), severe (43.1%), very severe (5.2%) and mild (1.7%) COPD. Most patients (52.6%) took 61-90 seconds for 15SCT. Post-15SCT SpO2 significantly decreased from baseline (92.9±2.3% vs. 96.3±1.3%; p<0.05). Patients with FEV1<50% had higher SpO2 reduction (4.37±1.12%) than those with FEV1 ³50% (2.51±0.96%). ROC analysis identified a ³3.5% SpO2 drop as indicative of severe airflow limitation with good sensitivity (80.4%), specificity (90.0%) positive predictive value (88.2%), and negative predictive value (83.1%).
Conclusion: Significant exercise-induced desaturation correlated with COPD severity, supporting 15SCT as a useful tool for predicting severe airflow limitation in stable COPD patients.
Chest Heart J. 2024; 48(1) : 12-18
Tasnuba Tahsin Tofa, Mahmud Rahim, Md Zahirul Islam et al.· Chest & Heart Journal· 0 citations
Background: Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway obstruction and systemic manifestations, leading to symptoms such as dyspnea and fatigue, which contribute to a typical behavior of physical inactivity and high sedentary time in daily life. However, it is still unclear whether disease knowledge has any correlation with this behavior. Aim: To identify whether the level of knowledge and disease self-management in individuals with COPD are correlated with higher levels of sedentary behavior, physical inactivity, or both. Methods: This is a cross-sectional study including individuals with COPD who underwent assessment of physical activity in daily life over seven consecutive days using an accelerometer. Additionally, pulmonary function was assessed by spirometry, and disease knowledge was evaluated using the Understanding COPD (UCOPD) and the Pulmonary Rehabilitation Adapted Index of Self-Efficacy (PRAISE) questionnaires. Results: 34 individuals with COPD were analyzed (17 men, 69±6 years, FEV 1 48±19% predict). Only weak or non-existing and not statistically significant correlations were observed between time spent/day in activities of moderate-to-vigorous intensity (MVPA) and the PRAISE and UCOPD questionnaires (r = 0.25 and 0.10, respectively, p > 0.05 for both), as well as between sedentary time and the same instruments (r = -0.05 and 0.25, respectively, p >0.05 for both). Conclusion: In individuals with COPD, the level of physical inactivity and sedentary behavior are not well correlated with the knowledge and self-management of the disease
Heloisa Krokoch, Thais Moçatto Tofoli, L. Santin et al.· Brazilian Journal of Respira...· 0 citations
Background:
Nocturnal oxygen desaturation (NOD) is a common but underrecognized phenomenon in chronic obstructive pulmonary disease (COPD), contributing to disease progression and adverse clinical outcomes. Its association with disease severity and clinical predictors remains inadequately explored in resource-limited settings.
Methods:
A hospital-based cross-sectional analytical study was conducted from August 2025 to January 2026 among 100 clinically stable COPD patients. Data on demographic and clinical variables were collected, and COPD severity was classified using GOLD criteria. Nocturnal oxygen desaturation was assessed using overnight pulse oximetry, while exercise-induced desaturation was evaluated using the six-minute walk test (6-MWT). Statistical analysis was performed using SPSS version 26.0. Associations were assessed using chi-square test, and predictors were identified using univariate and multivariate logistic regression.
Results:
The prevalence of nocturnal oxygen desaturation was 58%. NOD increased significantly with COPD severity, from 16.7% in GOLD I to 90.9% in GOLD IV (p<0.001). On multivariate analysis, independent predictors of NOD included age >60 years (AOR 1.8, p=0.03), smoking (AOR 2.6, p=0.004), BMI <18.5 kg/m² (AOR 2.1, p=0.02), COPD duration ≥5 years (AOR 1.9, p=0.04), GOLD stage III–IV (AOR 3.5, p<0.001), and 6-MWT desaturation (AOR 5.2, p<0.001).
Conclusion:
Nocturnal oxygen desaturation is highly prevalent in COPD and strongly associated with disease severity and key clinical factors. Early identification using simple screening tools such as pulse oximetry and 6-MWT may facilitate timely intervention and improve clinical outcomes.
Thirumagal R, E. Abraham, Ghanshyam Verma· Adolescência e Saúde· 0 citations