A mechanism-driven approach is adopted to systematically examine SNHG1 dysregulation and its roles in cancer, which complements existing literature and provides a clear framework for future SNHG1 research.
Abstract
: Small nucleolar RNA host genes (SNHGs) generate both long non-coding RNAs and small nucleolar RNAs from the same primary transcripts. Among the 32 identified members, SNHG1 is the most extensively studied and primarily acts as an oncogene. This review adopts a mechanism-driven approach to systematically examine SNHG1 dysregulation and its roles in cancer. Specifically, we address: (1) how SNHG1 is transcriptionally and post-transcriptionally dysregulated in tumors; (2) the molecular mechanisms by which it regulates gene expression, including epigenetic mechanisms (histone modifications, DNA methylation), transcriptional regulation, post-transcriptional regulation (mRNA stability, microRNA sponging), and protein-level regulation; and (3) how these mechanisms collectively drive cancer behaviors such as proliferation, migration, epithelial-to-mesenchymal transition, apoptosis, and ferroptosis. We also discuss potential crosstalk among SNHG1, circadian rhythm, and the nervous system, and identify major knowledge gaps, including isoform-specific functions, tumor-suppressive contexts, and challenges in clinical translation. Experimental roadmaps are proposed to address these open questions. This mechanism-focused synthesis complements existing literature and provides a clear framework for future SNHG1 research.
This review examines how different types of ncRNAs contribute to cancer initiation, progression, and treatment resistance, and assesses their potential as diagnostic markers, prognostic factors, and therapeutic targets.
Akanksha Samuel, G. Calin· Carcinogenesis· 0 citations
Hepatocellular carcinoma (HCC) is a malignant neoplasm characterized by high incidence and mortality rates globally. Its pathogenesis and progression are intricate and multifaceted, necessitating comprehensive analysis and elucidation. Recent studies have demonstrated that non-coding RNAs (such as long non-coding RNAs, circular RNAs, and microRNAs) and alternative splicing, which are central to post-transcriptional regulation, engage in extensive regulatory interactions. These interactions form a complex regulatory network that significantly influences the malignant properties such as stemness, proliferation, invasion, metastasis, metabolic reprogramming, tumor microenvironment, and drug sensitivity in liver cancer cells. This review systematically explores the molecular mechanisms underlying the interactions between non-coding RNAs and alternative splicing events, highlighting the role of this regulatory network in modulating the expression of oncogenes and tumor suppressor genes in HCC. Additionally, this review investigates the prospective application of pivotal molecules within this regulatory network as novel diagnostic biomarkers and therapeutic targets. It also analyzes the challenges and obstacles encountered in the clinical translation process, thereby providing new insights for research on the precision diagnosis and treatment of HCC.
An integrated overview of the molecular features and functional roles of BAP1 is provided, with particular emphasis on its impacts on the regulation of cell death including apoptosis, ferroptosis and disulfidptosis.
Kexin Fan, Jun Yao, Shaobo Wu et al.· Frontiers in Cell and Develo...· 0 citations
This study uncovers a therapeutic vulnerable lncRNA-centric circuitry and provides compelling preclinical evidence for the development and application of a novel RNA targeting-LNP based therapy for treatment of myeloid leukemia.
Zhenggen Jin, Brendan D. Ma, Karen Y. T. Chan et al.· bioRxiv· 0 citations
This review integrates the molecular logic of splice-site selection with the cancer-specific mechanisms that perturb it, summarizes representative isoform switches across the hallmarks of cancer, evaluates emerging technologies and clinical biomarkers, and discusses the opportunities and constraints of translating splicing biology into precision oncology.
Numerous recent studies have shown that long noncoding RNAs (lncRNAs) play a crucial role in the development of diverse cancers. Small nucleolar RNA host gene 18 (SNHG18) is a cancer‐related lncRNA in the SNHG family, whose expression is dysregulated in various tumors and acts as either an oncogenic or tumor‐suppressive factor. Several studies have demonstrated that SNHG18 exhibits dual effects in various cancers. The role of this molecule is context‐dependent, acting as a tumor suppressor in certain cancers while exhibiting oncogenic properties in others. The expression of SNHG18 is cancer‐type specific: it is upregulated in glioma, multiple myeloma, and lung cancer, but downregulated in bladder and hepatocellular cancer. Clinical studies have also found a correlation between SNHG18 expression and prognosis in different cancers. We present an overview of studies on SNHG18, emphasizing its biological functions and its potential as a promising biomarker for the diagnosis and treatment of diverse cancer types.
Vida Dehghani Champiri, S. Asgharzade· BioMed Research Internationa...· 0 citations