Dynamic Co‐Evolution of Obesity‐Metabolic‐Inflammatory for Cardiovascular Disease Risk Stratification in Middle‐Aged and Older Adults: A Data‐Driven Joint Trajectory Analysis
Cardiovascular disease (CVD) risk assessment based on single‐time‐point measurements may inadequately capture the dynamic interplay of obesity, metabolic dysfunction, and chronic inflammation. Understanding their long‐term co‐evolution may improve CVD risk stratification.
Conventional BMI‐based obesity classification fails to capture the metabolic heterogeneity underlying obesity‐related heart failure (HF) risk. We evaluated the 2024 European Association for the Study of Obesity (EASO) framework—which integrates central adiposity with medical, functional, and psychological morbidity—to...
Depression and long‐term HbA1c variability are associated with adverse outcomes in type‐2 diabetes (T2D), which may be related to suboptimal self‐management practices and health‐related quality of life (HRQoL).
K. Wong, E. W. Chow, E. Lau et al.· Diabetes/Metabolism Research...· 0 citations
Cardiovascular–kidney–metabolic (CKM) syndrome links metabolic, kidney, and cardiovascular disorders, but its burden among women of reproductive age (WRA) remains poorly understood. We quantified the global burden and trends of key CKM‐related conditions and high body mass index (BMI)‐attributable burden among WRA.
Cui-Ping Jiang, Jieyuzhen Qiu, Chuan-Li Wei et al.· Journal of Evidence-Based Me...· 0 citations
The cognitive implications of longitudinal frailty exposure remain unclear. We examined associations of baseline frailty status, two‐wave frailty change, and mean frailty burden with annual cognitive change and cognitive aging trajectories.
