Joint impact of pathological burden and cognitive resilience on Alzheimer's disease risk.

Zhi-Bo Wang Shu-Heng Wang Yu-Mei Liang Xin-Lei Chen Si-Miao Wang W. Qin Qi Wang Yan Li Tan Zhao Yue Wang Fang Li Guo-Guang Zhao Jian-Ping Jia

Sep 2026 · Nature Medicine · 1 citation · 35 references

Medicine

TL;DR

The findings broaden the understanding that AD dementia is shaped jointly by pathological burden and cognitive resilience, and argue for therapeutic trial and prevention strategies that strengthen resilience alongside reducing pathology.

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