These findings systematically elucidate the biosynthesis of monoterpenoids in A. annua and provide key enzymatic elements for metabolic engineering and synthetic biology applications in monoterpenoid production.
This review summarizes recent advances in monoterpenoid biosynthesis, multilevel regulation, and heterologous production, with particular emphasis on major bottlenecks and optimization strategies for sustainable and efficient biomanufacturing.
Jun-Chi Zhang, Jiale Cui, Shang Li et al.· Natural Products and Biopros...· 0 citations
Findings reveal tissue-specific metabolite accumulation and key genes involved in MIA biosynthesis in N. cadamba that provide valuable insights into specialized metabolism and establish a foundation for future metabolic engineering and functional genomics studies.
Divya Selvakumar, G. Ramalingam, Suganya Balan et al.· Molecular Biology Reports· 0 citations
The results define the gene-to-metabolite relationships within the TPS-b subfamily in M. truncatula and expand the known enzymatic biosynthetic capacity underlying oxygenated monoterpene biosynthesis in plants.
Background Eupatorium lindleyanum is a medicinal plant rich in bioactive sesquiterpenoids, yet the genetic and regulatory basis underlying their biosynthesis remains completely unexplored. In particular, the marked tissue-specific accumulation of these compounds—abundant in aerial organs but scarce in roots—lacks a mol...
Ying-Zhe Wang, Pan Jiang, Jia-Qiu Yuan et al.· PLoS ONE· 0 citations
Terpenoids are among the most chemically diverse natural product classes in the plant kingdom and are a source of numerous nature-inspired human medicines. One specific subclass, diterpenoids, defined by a C20 skeleton, includes attractive compounds such as the anticancer drug Taxol, the sweetener steviol, and the pl...
D. Domingo-Fernándéz, P. Slack, Ifra Saifi et al.· Journal of Natural Products· 0 citations
This review discusses the structural diversity and bioactivity of representative tetracyclic and pentacyclic triterpenoids, such as ginsenosides, licorice triterpenoids, mogrosides, saikosaponins, and lupeol-type triterpenoids, and systematically summarizes the key enzyme families involved.
Lin Xiang, Lin-Hao Chen, Bo Lv et al.· Advances in Biochemical Engi...· 0 citations
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