Aug 2026· Developmental Cell· Vol 61 8, pp.
1593-1594
· 0 citations· 8 references
Medicine
TL;DR
Two parallel neuronal circuits that non-cell-autonomously regulate muscle autophagy in C. elegans are identified, revealing an unexpected role for the nervous system in orchestrating peripheral autophagy.
Abstract
Autophagy is commonly viewed as a cell-autonomous degradative process governed by intracellular metabolic and stress signals,1 but how autophagy is coordinated across tissues in multicellular organisms remains unclear. Zheng et al. 2 identify two parallel neuronal circuits that non-cell-autonomously regulate muscle autophagy in C. elegans, revealing an unexpected role for the nervous system in orchestrating peripheral autophagy.
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