Aug 2026· Cell Chemical Biology· Vol 33 8, pp.
1071-1073
· 0 citations· 8 references
Medicine
TL;DR
It is demonstrated that allosteric modulation of the mitochondrial protein Miro1 can selectively reprogram mitochondrial stress signaling and can produce distinct responses in disease-relevant cell types, despite acting within a broadly conserved stress pathway.
Abstract
In this issue of Cell Chemical Biology, Chandra and colleagues1 demonstrate that allosteric modulation of the mitochondrial protein Miro1 can selectively reprogram mitochondrial stress signaling. Chemical targeting of a single molecular hub can produce distinct responses in disease-relevant cell types, despite acting within a broadly conserved stress pathway.
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