Aug 2026· Translational Oncology· Vol 72, pp. 102989· 0 citations· 25 references
Medicine
TL;DR
High-resolution mapping of 52,384 cells uncovers hierarchical intra-tumor heterogeneity in HCC and TMEM176B is identified as the link between tumor malignancy hierarchy and immune remodeling.
Abstract
Highlights • Single-cell landscape:High-resolution mapping of 52,384 cells uncovers hierarchical intra-tumor heterogeneity in HCC.• Key molecule discovery:TMEM176B is identified as the link between tumor malignancy hierarchy and immune remodeling.• Poor prognosis marker: TMEM176B low expression correlates with reduced overall survival (p = 0.021).• Functional validation: TMEM176B overexpression inhibits tumor growth; positively correlates with CXCL9/10 and PD-L1/CTLA-4.
Highlights • Seven MM-specific M2-TAM subsets (MM-M2) are absent in normal bone marrow.• MM-M2 subclusters exhibit distinct transcription factor programs via SCENIC.• Enhanced ligand–receptor signaling links MM-M2 to plasma and stromal cells.• An 11-gene RSF-derived MRGs signature stratifies MM patients by survival.• M...
Hui Zhao, Jing Kang, H. Ouyang et al.· Translational Oncology· 0 citations
Highlights • BSG is significantly upregulated in lung adenocarcinoma (LUAD) tissues.• High BSG expression is an independent prognostic factor for poor survival in LUAD.• BSG expression negatively correlates with the infiltration of key anti-tumor immune cells.• BSG is closely associated with immune checkpoint molecules...
Intrahepatic cholangiocarcinoma (ICC) is a rare but highly aggressive primary liver malignancy distinguished by a profoundly heterogeneous tumor microenvironment, which underlies its limited response to targeted and immune-based therapies. Deciphering the cellular composition and intercellular signaling within this com...
Guo-Liang Wang, Hang Meng, Meng Li et al.· Genomics, Proteomics & Bioin...· 0 citations
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