Transmembrane glycoprotein BSG serves a dual role as a prognostic and immunological modulator in the tumor microenvironment of lung adenocarcinoma

Abstract

Highlights • BSG is significantly upregulated in lung adenocarcinoma (LUAD) tissues.• High BSG expression is an independent prognostic factor for poor survival in LUAD.• BSG expression negatively correlates with the infiltration of key anti-tumor immune cells.• BSG is closely associated with immune checkpoint molecules and chemokine networks.• Experimental validation confirms BSG's protein expression and prognostic relevance in LUAD.