Integrating single-cell and bulk RNA data to explore the prognostic significance of LIM domain family genes in colorectal cancer and unveil their immune landscape
Aug 2026· Translational Oncology· Vol 72, pp. 102974· 0 citations· 73 references
Medicine
TL;DR
It was revealed that cells with high LIM scores were predominantly fibroblasts, and Erlotinib, fulvestrant, EPZ5676, and AZD1208 were identified as potential therapeutic agents for patients in the low-LIMRS group, whereas vinblastine, docetaxel, paclitaxel, and vinorelbine may be more suitable for high-LIMRS group patients.
Abstract
Highlights • This study revealed that cells with high LIM scores were predominantly fibroblasts.• A risk model constructed from nine LIM domain family signature genes (CRYAB, RGS16, CSRP2, RCAN2, TPM1, EGFL7, PLS3, PDGFRA, and PLAU) accurately predicted the prognosis of CRC patients.• Erlotinib, fulvestrant, EPZ5676, and AZD1208 were identified as potential therapeutic agents for patients in the low-LIMRS group, whereas vinblastine, docetaxel, paclitaxel, and vinorelbine may be more suitable for high-LIMRS group patients.
Colorectal cancer (CRC) remains a leading cause of cancer mortality. This study investigates the prognostic and immunological role of neural-related genes (NRGs) in CRC. Using The Cancer Genome Atlas (TCGA) data, a four-gene signature (POU4F1, KLC3, ATP2A1, CALB2) was constructed via Cox and least absolute shrinkage an...
To develop an innovative prognostic model for colon adenocarcinoma (COAD), we integated anoikis- and cell matrix adhesion (CMA related mechanisms using TCGA and GEO datasets. Six genes (BST2, NAT1, OFCC1, HOTAIR, TRIP6, ADAMTS13) were identified, risk model stratified patients into high- and low risk groups with distin...
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