Aug 2026· European Journal of Therapeutics· 0 citations· 21 references
TL;DR
T-PRF was associated with improved radiographic healing of extraction sockets, as reflected by a lower residual non-ossified socket volume after 3 months compared with spontaneous healing, which may represent a simple, autologous, and clinically useful adjunct for socket preservation prior to implant placement.
Abstract
Objective: Alveolar ridge remodeling following tooth extraction may compromise subsequent implant placement. Titanium-prepared platelet-rich fibrin (T-PRF) has been proposed as an autologous biomaterial that may enhance socket healing and minimize post-extraction dimensional changes. This study aimed to compare the radiographic healing of extraction sockets treated with T-PRF and those left to heal spontaneously using cone-beam computed tomography (CBCT)-based volumetric analysis.
Methods: A total of 30 systemically healthy patients (18 males and 12 females) requiring tooth extraction followed by implant placement were enrolled in this randomized clinical trial. A total of 58 extraction sockets were included, with 27 sockets allocated to the T-PRF group and 31 sockets assigned to spontaneous healing (control group). The initial CBCT examination (baseline assessment) was performed 7–10 days after tooth extraction, and a follow-up CBCT examination was performed 3 months after extraction. Baseline socket volume, residual non-ossified socket volume, and the estimated percentage of socket fill were assessed using dedicated volumetric analysis software. Because some participants contributed more than one extraction socket, generalized estimating equations (GEE) were used to account for within-patient clustering.
Results: Baseline socket volumes were comparable between the groups (p = 0.752). At 3 months, the residual non-ossified socket volume was significantly lower in the T-PRF group than in the control group (0.043 cm³ vs. 0.087 cm³; p = 0.013). Both groups demonstrated progressive socket healing over time; however, the estimated percentage of socket fill was significantly higher in the T-PRF group than in the control group (80.1% vs. 57.3%).
Conclusion: Within the limitations of this randomized clinical trial, T-PRF was associated with improved radiographic healing of extraction sockets, as reflected by a lower residual non-ossified socket volume after 3 months compared with spontaneous healing. T-PRF may represent a simple, autologous, and clinically useful adjunct for socket preservation prior to implant placement.
Within the limitations of this study, intentionally exposing the xenogeneic collagen matrix seal yielded comparable outcomes in non-contained and contained sockets, which may reflect the material's ability to reduce the adverse effects of socket-wall resorption.
Xinyi Zhou, Yuping Hong, Yang Yang et al.· Journal of Periodontal & Imp...· 0 citations
In edentulous maxilla with insufficient bone width, both the association of i-PRF+DBBM and DBBM alone were effective in providing bone width gain for implant placement, and the association of DBBM with i-PRF showed similar outcomes compared with DBBM alone for the studied parameters.
Gabriel Rodrigues Oliveira, Vínicius Fabris, Alfonso Sánchez-Ayala et al.· Clinical Oral Investigations· 0 citations
Background: Prolonged orthodontic treatment duration remains a major clinical concern because of its association with root resorption, enamel decalcification, periodontal complications, and reduced patient compliance. Injectable platelet-rich fibrin (I-PRF), a second-generation autologous platelet concentrate rich in growth factors and inflammatory mediators, has recently gained attention as a minimally invasive adjunct for accelerating orthodontic tooth movement (OTM). Aim was to evaluate the effectiveness of I-PRF on the rate of OTM during maxillary canine retraction.
Methods: This prospective split-mouth clinico-experimental study included nine patients requiring bilateral maxillary first premolar extractions for orthodontic treatment. The right maxillary quadrant received intraligamentary I-PRF injections, while the contralateral side served as the control. Canine retraction was performed using nickel-titanium closed-coil springs delivering 150 g force on 0.019″×0.025″ stainless steel archwires. I-PRF was prepared using low-speed centrifugation at 700 rpm for 3 minutes and administered at baseline and eighth week. OTM was evaluated monthly for three months using three-dimensional digital model superimposition. Statistical analysis included paired t-test, repeated measures ANOVA, and Bonferroni post-hoc analysis.
Results: The I-PRF group demonstrated greater OTM compared to the control group at all evaluated intervals. Statistically significant differences were observed during the initial phase of retraction and in cumulative tooth movement from baseline to the third month. Repeated measures ANOVA revealed significant variation in tooth movement across different intervals in both groups.
Conclusions: I-PRF demonstrated a positive effect on accelerating OTM and may serve as an effective, minimally invasive biologic adjunct for enhancing orthodontic treatment efficiency.
Benezer Rapsang, Vaibhav Misra, A. Garg et al.· International Journal of Cli...· 0 citations
Introduction: Alveolar ridge resorption is initiated rapidly within weeks following tooth extraction, therefore successful implant outcomes depend upon preservation of alveolar ridge. Techniques like atraumatic extraction and socket grafting helps in reduction of bone loss. Demineralised Freeze-dried Bone Allograft (DFDBA) is a commonly used due to its osteoinductive properties which are enhanced when combined with Advanced Platelet Rich Fibrin (A-PRF). A-PRF enhances healing and regeneration of both soft and hard-tissues. Autologous Dentin Graft (ADG), derived from extracted teeth, mimics natural bone and offers osteoinductive and osteoconductive benefits. Radiographic and histological analysis along with clinical evaluation are reliable methods to assess outcomes.
Need of the study: The ADG eliminates the need for a second surgical site and reduces patient morbidity. Furthermore, the combined effect of ADG with A-PRF has not yet been evaluated, highlighting the need for this study.
Aim: To assess and compare the effectiveness of DFDBA with A-PRF and ADG with A-PRF in socket preservation using clinical, radiographical, and histological analysis.
Materials and Methods: This randomised controlled clinical trial compares DFDBA with A-PRF and ADG with A-PRF in socket preservation. The trial will be conducted at the Department of Periodontics, Sharad Pawar Dental College, Sawangi (Meghe), Wardha, from May 2025 to June 2026, which will involve 10 participants in each group. Participants will be randomly assigned to one of two groups: (a) Socket preservation performed using DFDBA with A-PRF; (b) Socket preservation performed using ADG with A-PRF. Cone Beam Computed Tomography (CBCT) will be performed postoperatively and at four months, along with clinical evaluation and implant placement. Bone biopsies obtained during implant placement will be analysed histomorphometrically in a blinded manner. Statistical analysis will be performed using paired and unpaired Student’s t-tests, with a p-value <0.05 will be considered statistically significant.
Mahima Kothekar, Pavan Bajaj, Sneha Dare et al.· Journal of Clinical and Diag...· 0 citations
Using RST for socket sealing achieves comparable bone preservation to the GBR in severe defect molars, while simplifying the surgical procedure and reducing costs.
Background: Pulp necrosis in an immature permanent tooth disrupts root development, often treated with calcium hydroxide or Mineral Trioxide Aggregate (MTA) apexification, however, these approaches do not improve structural integrity of teeth. Regenerative endodontic therapy (RET) promotes root maturation, with blood clot and platelet-rich fibrin (PRF) commonly used as a scaffold. Injectable PRF (i-PRF) may offer enhanced biological properties. Aim: This study aimed to compare clinical and radiographic outcomes of RET using i-PRF and PRF in nonvital immature permanent teeth. Settings and Design: Department of Conservative Dentistry and Endodontics, Department of Paediatric Dentistry, Government Dental College, Thiruvananthapuram. Prospective Observational Study. Materials and Methods: Thirty-eight patients undergoing RET were allocated into two groups: Group I (i-PRF, n = 19) and Group II (PRF, n = 19). Clinical outcomes were assessed at 3, 6, and 12 months. Radiographic evaluation was performed at 6 and 12 months, including assessment of periapical healing using periapical index (PAI) scores, root development (length and dentinal wall thickness) measured using ImageJ, and apical responses evaluated according to the criteria described by Chen et al. Statistical analysis was performed with the level of significance set at P < 0.05. Results: Group I demonstrated a higher success rate (100%) and significantly greater reduction in PAI scores (P < 0.05) than Group II (89.47%). Both groups exhibited increases in root length and dentinal wall thickness without significant intergroup differences. Type 3 apical response was the predominant outcome, indicating ongoing root maturation with incomplete apical closure. No changes in coronal discoloration or vitality responses were observed at the 12-month follow-up. Conclusion: i-PRF demonstrated superior periapical healing and overall treatment outcomes compared to PRF, whereas both groups showed comparable effects on root development. These findings suggest that i-PRF may represent a promising biological scaffold for regenerative endodontic treatment of immature permanent teeth.
Tolivi T. Chishi, V. G. Sam Joseph, K. G. Vidya· Journal of conservative dent...· 0 citations